This review presents the accumulating evidence for the roles of protein phosphatase 6 (PP6)
in cell cycle, DNA damage repair, inflammatory signaling, lymphocyte development, virus …

The dynamic and stringent coordination of kinase and phosphatase activity controls a
myriad of physiologic processes. Aberrations that disrupt the balance of this interplay …

Background Thrombosis and hemorrhage as two opposite pathologies are prevalent within
the chronic kidney disease (CKD) population. Platelet homeostasis, which positions …

ASK1-JNK signaling promotes mitochondrial dysfunction-mediated apoptosis, but the bridge
between JNK and apoptosis is not fully understood. PUMA induces apoptosis through …

Overcoming drug resistance remains a key challenge to cure patients with acute and chronic
B cell malignancies. Here, we describe a stromal cell–autonomous signaling pathway …

Cell volume regulation is a vital system for cellular activities. When perturbed by
hypoosmotic or hyperosmotic stress, cells immediately induce the cell volume recovery …

Cisplatin-based chemotherapy is the primary treatment for metastatic bladder urothelial
carcinoma. However, the response rate is only 40–65%. This study investigated the anti …

Aims This study aimed to investigate the effect and mechanism of methylcrotonyl-CoA
carboxylase subunit 1 (MCCA) on multidrug resistance in multiple myeloma (MM). Materials …

Ppp6c, which encodes the catalytic subunit of phosphoprotein phosphatase 6 (PP6), is
conserved among eukaryotes from yeast to humans. In mammalian cells, PP6 targets IκBε …

Abstract The Bcl-2 homolog Bcl-xL is emerging as a key factor in tumorigenesis due to its
prominent pro-survival and cell death-independent functions. However, the regulation of Bcl …