Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Microglia are resident macrophages of the CNS that are involved in its development,
homeostasis and response to infection and damage. Microglial activation is a common …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Mounting evidence suggests that therapeutic cell and drug delivery strategies designed to
actively harness the regenerative potential of the inflammatory response have great …

MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

Myelination is an essential process that consists of the ensheathment of axons by myelin. In
the central nervous system (CNS), myelin is synthesized by oligodendrocytes. The …

Inflammation of the nervous system (neuroinflammation) is now recognized as a hallmark of
virtually all neurological disorders. In neuroinflammatory conditions such as multiple …

Ageing of the central nervous system results in a loss of both grey and white matter, leading
to cognitive decline. Additional injury to both the grey and white matter is documented in …

The regulation of inflammation is pivotal for preventing the development or reoccurrence of
multiple sclerosis (MS). A biased ratio of high‐M1 versus low‐M2 polarized microglia is a …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with high
mortality and morbidity rate affecting both upper and lower motor neurons (MN). Muscle …