The viral main protease is one of the most attractive targets among all key enzymes involved
in the SARS-CoV-2 life cycle. Covalent inhibition of the cysteine145 of SARS-CoV-2 MPRO …

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …

Targeted protein degradation has arisen as a powerful therapeutic modality for eliminating
proteins. Thus far, most heterobifunctional proteolysis targeting chimeras (PROTACs) have …

While the COVID-19 pandemic seems to be on its decline, the unclear impacts of long-
COVID cases, breakthrough infections in immunocompromised individuals, vaccine …

Antiviral therapeutics to treat SARS‐CoV‐2 are needed to diminish the morbidity of the
ongoing COVID‐19 pandemic. A well‐precedented drug target is the main viral protease …

Molecular docking plays a pivotal role in drug discovery and precision medicine, furnishing
insights into protein functionalities and fostering the development of therapeutics. Here, we …

In order to address the world-wide health challenge caused by the COVID-19 pandemic, the
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …

Organic compounds with pyrazole cores have a variety of uses, notably in the
pharmaceutical and agrochemical sectors. The interest in creating pyrazole compounds …

Les coronavirus sont une vaste famille de virus à ARN capables d'infecter de nombreuses
espèces d'oiseaux et de mammifères, dont l'Homme. Au total, sept coronavirus peuvent …