Interplay between inflammation and thrombosis in cardiovascular pathology
K Stark, S Massberg - Nature Reviews Cardiology, 2021 - nature.com
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
The role of platelets in immune-mediated inflammatory diseases
M Scherlinger, C Richez, GC Tsokos… - Nature Reviews …, 2023 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19
ED Hottz, IG Azevedo-Quintanilha… - Blood, The Journal …, 2020 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen
responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel …
responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel …
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
NLRP3 inflammasome—a key player in antiviral responses
C Zhao, W Zhao - Frontiers in immunology, 2020 - frontiersin.org
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
Pathophysiology of sickle cell disease
Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …
Cell type-specific roles of NF-κB linking inflammation and thrombosis
M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
Circulating platelets as mediators of immunity, inflammation, and thrombosis
M Koupenova, L Clancy, HA Corkrey… - Circulation …, 2018 - Am Heart Assoc
Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …
Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
The immune nature of platelets revisited
Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …
them with a variety of inflammatory processes. For example, platelets can act as circulating …