Simple Summary U2 small nuclear RNA auxiliary factor 1 (U2AF1) is one of the most
important RNA splicing genes involved in regulating the alternative splicing of pre-mRNA …

Histidine (His) residues are methylated in various proteins, but their roles and regulation
mechanisms remain unknown. Here, we show that carnosine N-methyltransferase 1 …

Simple Summary The spliceosome ribonucleoprotein complex catalyzes the removal of
introns and exons ligation, a fundamental post-transcriptional process that generates mature …

RNA splicing is a biological process to generate mature mRNA (mRNA) by removing introns
and annexing exons in the nascent RNA transcript and is executed by a multiprotein …

Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong hematopoiesis. Mutations
of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early …

Mutations in U2AF1 are relatively common in myelodysplastic neoplasms (MDS) and are
associated with an inferior prognosis, but the molecular mechanisms underlying this are not …

Transcriptomics is a powerful tool for unraveling the molecular effects of genetic variants and
disease diagnosis. Prior studies have demonstrated that choice of genome build impacts …

RNA splicing, a crucial transesterification-based process by which noncoding regions are
removed from premature RNA to create mature mRNA, regulates various cellular functions …

Allelic variation at the Ptprc gene, which encodes the pan-leukocyte marker CD45/Ly5, is
commonly exploited to track hematopoietic reconstitution by flow cytometry in mixed bone …

Mutations in RNA splicing factor genes including SF3B1, U2AF1, SRSF2, and ZRSR2 have
been reported to contribute to development of myeloid neoplasms including myelodysplastic …