Objective To review the current state of pharmaceutical treatment recommendations for the
management of osteoarthritis. Method A narrative review was drafted to describe treatment …

Patients with chronic non-malignant pain report impairment of physical and social life along
with psychological state affecting their overall quality of life. The purpose of managing pain …

Opioid use disorder is classified as a chronic recurrent disease of the central nervous
system (CNS) which leads to personality disorders, co-morbidities and premature death. It …

Suppression of the immune system has been constantly reported in the last years as a
classical side effect of opioid drugs. Most of the studies on the immunological properties of …

Opioids are mu receptor agonists and have been an important part of pain treatment for
thousands of years. In order to use these drugs appropriately and successfully in patients …

Analgesic design and evaluation have been driven by the desire to create high-affinity high-
selectivity mu (μ)-opioid peptide (MOP) receptor agonists. Such ligands are the mainstay of …

A method for the synthesis of substituted cycloalkanes was developed using diols and
secondary alcohols or ketones via a cascade hydrogen borrowing sequence. A non-noble …

Rugby is characterized by frequent high-intensity collisions, resulting in muscle soreness.
Players consequently seek strategies to reduce soreness and accelerate recovery, with an …

Herein, we report the stereoselective synthesis of (1+ n)-membered cycloalkane from methyl
ketone and 1, n-diol. A manganese (I) complex bearing a phosphine-free ligand catalyzed …

Tramadol—an atypical opioid analgesic—has a unique pharmacokinetic and
pharmacodynamic profile, with opioidergic, noradrenergic, and serotonergic actions …