Diabetes mellitus (DM) is considered as a main challenge in both developing and
developed countries, as lifestyle has changed and its management seems to be vital. Type I …

Abstract Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding
protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and …

Background Doxorubicin-induced cardiotoxicity (DIC) limits the clinical application of the
drug in treatment of cancers and imposes a severe health burden on the patients. Therefore …

Mitochondrial dysfunction and oxidative stress-mediated inflammasome activation play
critical roles in the pathogenesis of the non-alcoholic fatty liver disease (NAFLD). Non …

Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia
and diabetes. These three metabolic disorders can occur simultaneously, hence, the …

The inflammasome is a protein complex composed of a variety of proteins in cells and which
participates in the innate immune response of the body. It can be activated by upstream …

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with type 2 diabetes mellitus
(T2DM). Sesquiterpene glycosides from loquat leaf achieved beneficial effects on metabolic …

Background and Aims NASH is becoming a leading cause of liver cirrhosis and HCC.
Salidroside (p‐hydroxyphenethyl‐β‐D‐glucoside; SAL) has various biological and …

With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most
prevalent liver disease worldwide. A substantial increase in the incidence, mortality, and …

Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic
fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of …