Challenges and opportunities in NASH drug development

SA Harrison, AM Allen, J Dubourg, M Noureddin… - Nature medicine, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic
steatohepatitis (NASH), represent a growing worldwide epidemic and a high unmet medical …

Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

SL Friedman, M Pinzani - Hepatology, 2022 - Wiley Online Library
Steady progress over four decades toward understanding the pathogenesis and clinical
consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet …

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease

ME Rinella, BA Neuschwander-Tetri, MS Siddiqui… - Hepatology, 2023 - journals.lww.com
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AI, artificial
intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC …

Semaglutide 2· 4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial

R Loomba, MF Abdelmalek, MJ Armstrong… - The Lancet …, 2023 - thelancet.com
Background Patients with non-alcoholic steatohepatitis (NASH)-related cirrhosis are at high
risk of liver-related and all-cause morbidity and mortality. We investigated the efficacy and …

A researcher's guide to preclinical mouse NASH models

S Gallage, JEB Avila, P Ramadori, E Focaccia… - Nature …, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …

Current therapies and new developments in NASH

JF Dufour, QM Anstee, E Bugianesi, S Harrison… - Gut, 2022 - gut.bmj.com
Non-alcoholic steatohepatitis is becoming the most important aetiology for advanced liver
disease. There has been important progress in the field in recent years and the complexity of …

Clinical applications of artificial intelligence—an updated overview

Ș Busnatu, AG Niculescu, A Bolocan… - Journal of clinical …, 2022 - mdpi.com
Artificial intelligence has the potential to revolutionize modern society in all its aspects.
Encouraged by the variety and vast amount of data that can be gathered from patients (eg …

[HTML][HTML] Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label …

N Alkhouri, R Herring, H Kabler, Z Kayali… - Journal of …, 2022 - Elsevier
Background & Aims Non-alcoholic steatohepatitis (NASH) is associated with increased risk
of liver-related and cardiovascular morbidity and mortality. Given the complex …

Artificial intelligence for digital and computational pathology

AH Song, G Jaume, DFK Williamson, MY Lu… - Nature Reviews …, 2023 - nature.com
Advances in digitizing tissue slides and the fast-paced progress in artificial intelligence,
including deep learning, have boosted the field of computational pathology. This field holds …

[HTML][HTML] Artificial intelligence in liver diseases: Improving diagnostics, prognostics and response prediction

D Nam, J Chapiro, V Paradis, TP Seraphin, JN Kather - Jhep Reports, 2022 - Elsevier
Clinical routine in hepatology involves the diagnosis and treatment of a wide spectrum of
metabolic, infectious, autoimmune and neoplastic diseases. Clinicians integrate qualitative …