Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …

Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

In the past 2 years, there continue to be advances in our understanding of the genetic and
epigenetic underpinnings of atopy pertaining to disease risk and disease severity. The joint …

The epigenome is at the intersection of the environment, genotype, and cellular response.
DNA methylation of cytosine nucleotides, the most studied epigenetic modification, has been …

Background Albuterol is the drug most widely used as asthma treatment among African
Americans despite having a lower bronchodilator drug response (BDR) than other …

Further research is needed to explore the diagnostic and therapeutic potential of epigenetic
modifications in asthma. Multiomics studies on asthma will become increasingly important …

Asthma, a chronic respiratory disease with a global prevalence of approximately 300 million
individuals, presents a significant societal and economic burden. This multifaceted …

Hypomethylating agents (HMAs) have been used for decades in the treatment of
hematologic neoplasms, and now, have gathered attention again in terms of their …

Asthma is a complex disease with significant genetic and environmental contributions to risk,
and substantial heterogeneity with respect to the age of onset, associated comorbidities …