Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …
photochemical properties of transition metal complexes for diagnostic and therapeutic …
Visible-light-mediated modification and manipulation of biomacromolecules
Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …
have become crucial tools in chemical biology. They are extensively used not only to …
Activating innate immunity by a STING signal amplifier for local and systemic immunotherapy
W Song, SJ Song, J Kuang, H Yang, T Yu, F Yang… - ACS …, 2022 - ACS Publications
The number of patients who benefit from acquired immunotherapy is limited. Stimulator of
interferon genes (STING) signal activation is a significant component to enhance innate …
interferon genes (STING) signal activation is a significant component to enhance innate …
Strategies for the nuclear delivery of metal complexes to cancer cells
M Huynh, R Vinck, B Gibert, G Gasser - Advanced Materials, 2024 - Wiley Online Library
The nucleus is an essential organelle for the function of cells. It holds most of the genetic
material and plays a crucial role in the regulation of cell growth and proliferation. Since …
material and plays a crucial role in the regulation of cell growth and proliferation. Since …
“Dual-key-and-lock” ruthenium complex probe for lysosomal formaldehyde in cancer cells and tumors
Biomedical investigations reveal that excessive formaldehyde generation is possibly a
critical factor for tissue cancerization, cancer progression, and metastasis. Responsive …
critical factor for tissue cancerization, cancer progression, and metastasis. Responsive …
Organic thermally activated delayed fluorescence materials for time‐resolved luminescence imaging and sensing
As one of the most attractive purely organic luminescent materials, thermally activated
delayed fluorescence (TADF) luminophores have drawn wide attention in the last decade …
delayed fluorescence (TADF) luminophores have drawn wide attention in the last decade …
Anticancer cyclometalated iridium (III) complexes with planar ligands: mitochondrial DNA damage and metabolism disturbance
Emerging studies have shown that mitochondrial DNA (mtDNA) is a potential target for
cancer therapy. Herein, six cyclometalated Ir (III) complexes Ir1–Ir6 containing a series of …
cancer therapy. Herein, six cyclometalated Ir (III) complexes Ir1–Ir6 containing a series of …
Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy
Ruthenium complex is an important compound group for antitumor drug research and
development. NAMI-A, KP1019, TLD1433 and other ruthenium complexes have entered …
development. NAMI-A, KP1019, TLD1433 and other ruthenium complexes have entered …
A Tailored multifunctional anticancer nanodelivery system for ruthenium‐based photosensitizers: tumor microenvironment adaption and remodeling
JH Liang, Y Zheng, XW Wu, CP Tan, LN Ji… - Advanced …, 2020 - Wiley Online Library
Ruthenium complexes are promising photosensitizers (PSs), but their clinical applications
have many limitations. Here, a multifunctional nano‐platform PDA‐Pt‐CD@ RuFc formed by …
have many limitations. Here, a multifunctional nano‐platform PDA‐Pt‐CD@ RuFc formed by …
Mechanisms of action of Ru (II) polypyridyl complexes in living cells upon light irradiation
The unique photophysical properties of Ru (II) polypyridyl complexes make them very
attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date …
attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date …