Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE,
humans) are an emerging behavioral intervention approach based on the understanding of …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

Microbiota-derived short-chain fatty acids (SCFAs) and organic acids produced by the
fermentation of non-digestible fibre can communicate from the microbiome to host tissues …

Characteristics of the gut microbiome vary synchronously with changes in host diet.
However, the underlying effects of these fluctuations remain unclear. Here, we performed …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Circadian clock proteins are endogenous timing mechanisms that control the transcription of
hundreds of genes. Their integral role in coordinating metabolism has led to their scrutiny in …

Terrestrial organisms developed circadian rhythms for adaptation to Earth's quasi-24-h
rotation. Achieving precise rhythms requires diurnal oscillation of fundamental biological …