Pathological epigenetic events and reversibility review: the intersection between hallmarks of aging and developmental origin of health and disease
DM Ruden, A Singh, DA Rappolee - Epigenomics, 2023 - Taylor & Francis
We discuss pathological epigenetic events that are reversible (PEERs). A recent study by
Poganik and colleagues showed that severe stress in mice and humans transiently elevates …
Poganik and colleagues showed that severe stress in mice and humans transiently elevates …
[HTML][HTML] Translational toxicoepigenetic meta-analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead …
Although toxicology uses animal models to represent real-world human health scenarios, a
critical translational gap between laboratory-based studies and epidemiology remains. In …
critical translational gap between laboratory-based studies and epidemiology remains. In …
Early-life exposure to lead changes cardiac development and compromises long-term cardiac function
Q Liu, C Xu, J Jin, W Li, J Liang, S Zhou, Z Weng… - Science of The Total …, 2023 - Elsevier
Lead (Pb) is widely used in industrial and daily-use consumer products. Early-life exposure
may increase the risk of lead-related heart problems in childhood. However, the effects of …
may increase the risk of lead-related heart problems in childhood. However, the effects of …
Firefighting, per‐and polyfluoroalkyl substances, and DNA methylation of genes associated with prostate cancer risk
M Quaid, JM Goodrich, MM Calkins… - Environmental and …, 2024 - Wiley Online Library
Prostate cancer is the leading incident cancer among men in the United States. Firefighters
are diagnosed with this disease at a rate 1.21 times higher than the average population …
are diagnosed with this disease at a rate 1.21 times higher than the average population …
Sex-Specific Deflection of Age-Related DNA Methylation and Gene Expression in Mouse Heart by Perinatal Toxicant Exposures
Background: Global and site-specific changes in DNA methylation and gene expression are
associated with cardiovascular aging and disease, but how toxicant exposures during early …
associated with cardiovascular aging and disease, but how toxicant exposures during early …
[HTML][HTML] Toxic metals in pregnancy and congenital heart defects. Insights and new perspectives for a technology-driven reduction in food sources
Congenital heart defects (CHD) represent the most frequent congenital anomalies among
newborns, as well as the leading cause of spontaneous abortion, stillbirth, neonatal and …
newborns, as well as the leading cause of spontaneous abortion, stillbirth, neonatal and …