Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery
Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …
many gateways for the research in therapeutics. iPSCs are the cells which are …
Roles for Hedgehog signaling in adult organ homeostasis and repair
R Petrova, AL Joyner - Development, 2014 - journals.biologists.com
The hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions
during development, and HH signaling continues in discrete populations of cells within …
during development, and HH signaling continues in discrete populations of cells within …
[HTML][HTML] Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
Brain disorders are characterized by the progressive loss of structure and function of the
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …
involved during embryonic development and later life stages. Further, it regulates cell …
Sonic Hedgehog signaling in the mammalian brain
E Traiffort, E Angot, M Ruat - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 113, 576–590. Abstract The discovery of a Sonic Hedgehog (Shh)
signaling pathway in the mature vertebrate CNS has paved the way to the characterization …
signaling pathway in the mature vertebrate CNS has paved the way to the characterization …
Sonic hedgehog protects cortical neurons against oxidative stress
RL Dai, SY Zhu, YP Xia, L Mao, YW Mei, YF Yao… - Neurochemical …, 2011 - Springer
Oxidative stress is one of the most important pathological mechanisms in neurodegenerative
diseases and ischemia. Recent studies have indicated that the sonic hedgehog (SHH) …
diseases and ischemia. Recent studies have indicated that the sonic hedgehog (SHH) …
Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders
LY Al-Ayadhi - Neurochemical research, 2012 - Springer
The etiology of autism spectrum disorders (ASD) is not well known but oxidative stress has
been suggested to play a pathological role. We report here that the serum levels of Sonic …
been suggested to play a pathological role. We report here that the serum levels of Sonic …
bone marrow-derived mesenchymal stem cell-derived exosomes containing Gli1 alleviate microglial activation and neuronal apoptosis in vitro and in a mouse …
Y Cai, MM Zhang, M Wang, ZH Jiang… - … of Neuropathology & …, 2022 - academic.oup.com
This study investigated possible therapeutic effect mechanisms of exosomes from bone
marrow-derived mesenchymal stem cells (BMSC) in neuronal and microglial cells and in a …
marrow-derived mesenchymal stem cells (BMSC) in neuronal and microglial cells and in a …
Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection
CI Ugbode, I Smith, BJ Whalley… - Journal of …, 2017 - Wiley Online Library
Sonic hedgehog (SHH) is a glycoprotein associated with development that is also
expressed in the adult CNS and released after brain injury. Since the SHH receptors …
expressed in the adult CNS and released after brain injury. Since the SHH receptors …
Aging of signal transduction pathways, and pathology
ME Carlson, HS Silva, IM Conboy - Experimental cell research, 2008 - Elsevier
The major cell signaling pathways, and their specific mechanisms of transduction, have
been a subject of investigation for many years. As our understanding of these pathways …
been a subject of investigation for many years. As our understanding of these pathways …