CB1 receptor signaling in the brain: extracting specificity from ubiquity
Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …
nervous system. Over the past few decades, observations based on a large volume of work …
Neurobiology of cannabinoid receptor signaling
B Lutz - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …
system. Despite its widespread localization, its functions within the context of distinct neural …
Mechanisms of endocannabinoid control of synaptic plasticity
BL Winters, CW Vaughan - Neuropharmacology, 2021 - Elsevier
The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks
G Morris, K Walder, S Kloiber, P Amminger… - Pharmacological …, 2021 - Elsevier
The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias
The type-1 cannabinoid receptor (CB 1) is a promising drug target for a wide range of
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …
Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway
I Ibarra-Lecue, I Mollinedo-Gajate, JJ Meana… - …, 2018 - nature.com
Long-term use of potent cannabis during adolescence increases the risk of developing
schizophrenia later in life, but to date, the mechanisms involved remain unknown. Several …
schizophrenia later in life, but to date, the mechanisms involved remain unknown. Several …
Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer
S Blasco-Benito, E Moreno… - Proceedings of the …, 2019 - National Acad Sciences
Although human epidermal growth factor receptor 2 (HER2)-targeted therapies have
dramatically improved the clinical outcome of HER2-positive breast cancer patients, innate …
dramatically improved the clinical outcome of HER2-positive breast cancer patients, innate …
Protein interactors and trafficking pathways that regulate the cannabinoid type 1 receptor (CB1R)
A Fletcher-Jones, KL Hildick, AJ Evans… - Frontiers in molecular …, 2020 - frontiersin.org
The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …
synaptic transmission and plays a major role in a diverse range of brain functions including …
[HTML][HTML] Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1 …
A García-Bea, P Miranda-Azpiazu, C Muguruza… - European …, 2019 - Elsevier
Abstract Serotonin 5-HT 2A receptors (5-HT 2A Rs) have been implicated in schizophrenia.
However, postmortem studies on 5-HT 2A Rs expression and functionality in schizophrenia …
However, postmortem studies on 5-HT 2A Rs expression and functionality in schizophrenia …