Drug repurposing to overcome microbial resistance

J Jampilek - Drug Discovery Today, 2022 - Elsevier
Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …

Antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance

M Lagadinou, MO Onisor, A Rigas, DV Musetescu… - Antibiotics, 2020 - mdpi.com
In recent years, due to the dramatic increase in and global spread of bacterial resistance to a
number of commonly used antibacterial agents, many studies have been directed at …

Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review

VS Foletto, TF da Rosa, MB Serafin, A Bottega… - International Journal of …, 2021 - Elsevier
The global spread of microbial resistance coupled with high costs and slow pace in the
discovery of a new antibiotic have made drug repositioning an attractive and promising …

Integration of terpesomes loaded Levocetrizine dihydrochloride gel as a repurposed cure for Methicillin-Resistant Staphylococcus aureus (MRSA)-Induced skin …

MM El-Naggar, MA El-Nabarawi, MH Teaima… - International Journal of …, 2023 - Elsevier
The intention of this work is to assess the repurposed antimicrobial impact of Levocetirizine
dihydrochloride (LVC), which is a well-known antihistaminic drug, in addition, to augment …

Antibacterial activity of antipsychotic agents, their association with lipid nanocapsules and its impact on the properties of the nanocarriers and on antibacterial activity

H Nehme, P Saulnier, AA Ramadan, V Cassisa… - PloS one, 2018 - journals.plos.org
Bacterial antibiotic resistance is an emerging public health problem worldwide; therefore,
new therapeutic strategies are needed. Many studies have described antipsychotic …

Insights into the reactivity properties, docking, DFT and MD simulations of orphenadrinium dihydrogen citrate in different solvents

JS Al-Otaibi, YS Mary, YS Mary, SJ Armaković… - Journal of Molecular …, 2022 - Elsevier
Experimental and theoretical investigations of a novel compound, Orphenadrinium
dihydrogen citrate (ODC) are reported. Wavenumbers are assigned by means of vibrational …

Cilia stimulatory and antibacterial activities of T2R bitter taste receptor agonist diphenhydramine: insights into repurposing bitter drugs for nasal infections

LE Kuek, DB McMahon, RZ Ma, ZA Miller, JF Jolivert… - Pharmaceuticals, 2022 - mdpi.com
T2R bitter taste receptors in airway motile cilia increase ciliary beat frequency (CBF) and
nitric oxide (NO) production. Polymorphisms in some T2Rs are linked to disease outcomes …

[HTML][HTML] Exposure to okadaic acid could disrupt the colonic microenvironment in rats

Y Liu, T Yuan, J Zheng, D Li, Y Jiao, H Li, R Li… - Ecotoxicology and …, 2023 - Elsevier
Okadaic acid (OA) is one of the most prevalent marine phycotoxin with complex toxicity,
which can lead to toxic symptoms such as diarrhea, vomiting, nausea, abdominal pain, and …

Drug repurposing for the treatment of staphylococcal infections

S Thangamani, H Mohammad… - Current …, 2015 - ingentaconnect.com
The development and approval of new antimicrobials capable of being used to treat
infections caused by multidrug-resistant pathogens has not kept pace with the rapid …

Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria

M Donnert, S Elsheikh, A Arce-Rodriguez… - PLoS …, 2020 - journals.plos.org
Embedded in an extracellular matrix, biofilm-residing bacteria are protected from diverse
physicochemical insults. In accordance, in the human host the general recalcitrance of …