Drug repurposing to overcome microbial resistance
J Jampilek - Drug Discovery Today, 2022 - Elsevier
Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …
Antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance
M Lagadinou, MO Onisor, A Rigas, DV Musetescu… - Antibiotics, 2020 - mdpi.com
In recent years, due to the dramatic increase in and global spread of bacterial resistance to a
number of commonly used antibacterial agents, many studies have been directed at …
number of commonly used antibacterial agents, many studies have been directed at …
Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review
VS Foletto, TF da Rosa, MB Serafin, A Bottega… - International Journal of …, 2021 - Elsevier
The global spread of microbial resistance coupled with high costs and slow pace in the
discovery of a new antibiotic have made drug repositioning an attractive and promising …
discovery of a new antibiotic have made drug repositioning an attractive and promising …
Integration of terpesomes loaded Levocetrizine dihydrochloride gel as a repurposed cure for Methicillin-Resistant Staphylococcus aureus (MRSA)-Induced skin …
The intention of this work is to assess the repurposed antimicrobial impact of Levocetirizine
dihydrochloride (LVC), which is a well-known antihistaminic drug, in addition, to augment …
dihydrochloride (LVC), which is a well-known antihistaminic drug, in addition, to augment …
Antibacterial activity of antipsychotic agents, their association with lipid nanocapsules and its impact on the properties of the nanocarriers and on antibacterial activity
H Nehme, P Saulnier, AA Ramadan, V Cassisa… - PloS one, 2018 - journals.plos.org
Bacterial antibiotic resistance is an emerging public health problem worldwide; therefore,
new therapeutic strategies are needed. Many studies have described antipsychotic …
new therapeutic strategies are needed. Many studies have described antipsychotic …
Insights into the reactivity properties, docking, DFT and MD simulations of orphenadrinium dihydrogen citrate in different solvents
JS Al-Otaibi, YS Mary, YS Mary, SJ Armaković… - Journal of Molecular …, 2022 - Elsevier
Experimental and theoretical investigations of a novel compound, Orphenadrinium
dihydrogen citrate (ODC) are reported. Wavenumbers are assigned by means of vibrational …
dihydrogen citrate (ODC) are reported. Wavenumbers are assigned by means of vibrational …
Cilia stimulatory and antibacterial activities of T2R bitter taste receptor agonist diphenhydramine: insights into repurposing bitter drugs for nasal infections
LE Kuek, DB McMahon, RZ Ma, ZA Miller, JF Jolivert… - Pharmaceuticals, 2022 - mdpi.com
T2R bitter taste receptors in airway motile cilia increase ciliary beat frequency (CBF) and
nitric oxide (NO) production. Polymorphisms in some T2Rs are linked to disease outcomes …
nitric oxide (NO) production. Polymorphisms in some T2Rs are linked to disease outcomes …
[HTML][HTML] Exposure to okadaic acid could disrupt the colonic microenvironment in rats
Okadaic acid (OA) is one of the most prevalent marine phycotoxin with complex toxicity,
which can lead to toxic symptoms such as diarrhea, vomiting, nausea, abdominal pain, and …
which can lead to toxic symptoms such as diarrhea, vomiting, nausea, abdominal pain, and …
Drug repurposing for the treatment of staphylococcal infections
S Thangamani, H Mohammad… - Current …, 2015 - ingentaconnect.com
The development and approval of new antimicrobials capable of being used to treat
infections caused by multidrug-resistant pathogens has not kept pace with the rapid …
infections caused by multidrug-resistant pathogens has not kept pace with the rapid …
Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria
M Donnert, S Elsheikh, A Arce-Rodriguez… - PLoS …, 2020 - journals.plos.org
Embedded in an extracellular matrix, biofilm-residing bacteria are protected from diverse
physicochemical insults. In accordance, in the human host the general recalcitrance of …
physicochemical insults. In accordance, in the human host the general recalcitrance of …