Sleep—A brain-state serving systems memory consolidation

S Brodt, M Inostroza, N Niethard, J Born - Neuron, 2023 - cell.com
Although long-term memory consolidation is supported by sleep, it is unclear how it differs
from that during wakefulness. Our review, focusing on recent advances in the field, identifies …

The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit

MN Modi, Y Shuai, GC Turner - Annual review of neuroscience, 2020 - annualreviews.org
The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …

[HTML][HTML] A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

BK Hulse, H Haberkern, R Franconville… - Elife, 2021 - elifesciences.org
Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

The connectome of the adult Drosophila mushroom body provides insights into function

F Li, JW Lindsey, EC Marin, N Otto, M Dreher… - Elife, 2020 - elifesciences.org
Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

[HTML][HTML] Re-examining the role of the dorsal fan-shaped body in promoting sleep in Drosophila

J De, M Wu, V Lambatan, Y Hua, WJ Joiner - Current Biology, 2023 - cell.com
The needs fulfilled by sleep are unknown, though the effects of insufficient sleep are
manifold. To better understand how the need to sleep is sensed and discharged, much effort …

Regulation of sleep by cholinergic neurons located outside the central brain in Drosophila

JD Jones, BL Holder, KR Eiken, A Vogt, AI Velarde… - PLoS …, 2023 - journals.plos.org
Sleep is a complex and plastic behavior regulated by multiple brain regions and influenced
by numerous internal and external stimuli. Thus, to fully uncover the function (s) of sleep …

[HTML][HTML] A paradoxical kind of sleep in Drosophila melanogaster

LAL Tainton-Heap, LC Kirszenblat, ET Notaras… - Current Biology, 2021 - cell.com
The dynamic nature of sleep in many animals suggests distinct stages that serve different
functions. Genetic sleep induction methods in animal models provide a powerful way to …

Developmental emergence of sleep rhythms enables long-term memory in Drosophila

AR Poe, L Zhu, M Szuperak, PD McClanahan… - Science …, 2023 - science.org
In adulthood, sleep-wake rhythms are one of the most prominent behaviors under circadian
control. However, during early life, sleep is spread across the 24-hour day. The mechanism …

Taste quality and hunger interactions in a feeding sensorimotor circuit

PK Shiu, GR Sterne, S Engert, BJ Dickson, K Scott - Elife, 2022 - elifesciences.org
Taste detection and hunger state dynamically regulate the decision to initiate feeding. To
study how context-appropriate feeding decisions are generated, we combined synaptic …

A neural circuit linking learning and sleep in Drosophila long-term memory

Z Lei, K Henderson, K Keleman - Nature Communications, 2022 - nature.com
Animals retain some but not all experiences in long-term memory (LTM). Sleep supports
LTM retention across animal species. It is well established that learning experiences …