Heart failure: an update from the last years and a look at the near future

M Riccardi, AM Sammartino, M Piepoli… - ESC heart …, 2022 - Wiley Online Library
In the last years, major progress occurred in heart failure (HF) management. Quadruple
therapy is now mandatory for all the patients with HF with reduced ejection fraction. Whilst …

The year in cardiovascular medicine 2020: heart failure and cardiomyopathies

H Bueno, B Moura, P Lancellotti… - European Heart …, 2021 - academic.oup.com
Heart failure (HF) prevalence remains high worldwide with significant sex-related and
regional differences in its presentation, management, and outcomes. In 2020, advances in …

Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial

W Doehner, SD Anker, J Butler, F Zannad… - European heart …, 2022 - academic.oup.com
Background The sodium-glucose cotransporter-2 inhibitor empagliflozin decreases the risk
of cardiovascular death or hospitalization for heart failure (HF) in patients with HF with …

Dapagliflozin reduces uric acid concentration, an independent predictor of adverse outcomes in DAPA‐HF

K McDowell, P Welsh, KF Docherty… - European journal of …, 2022 - Wiley Online Library
Aims Blood uric acid (UA) levels are frequently elevated in patients with heart failure and
reduced ejection fraction (HFrEF), may lead to gout and are associated with worse …

Lowering uric acid may improve prognosis in patients with hyperuricemia and heart failure with preserved ejection fraction

M Nishino, Y Egami, S Kawanami… - Journal of the …, 2022 - Am Heart Assoc
Background An association between uric acid (UA) and cardiovascular diseases, including
heart failure (HF), has been reported. However, whether UA is a causal risk factor for HF is …

[HTML][HTML] The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk

NR Pugliese, A Mengozzi, A Virdis, E Casiglia… - Clinical Research in …, 2021 - Springer
Introduction Serum uric acid (SUA) has been depicted as a contributory causal factor in
metabolic syndrome (MS), which in turn, portends unfavourable prognosis. Aim We …

Angiotensin receptor-neprilysin inhibitors: comprehensive review and implications in hypertension treatment

K Yamamoto, H Rakugi - Hypertension Research, 2021 - nature.com
Angiotensin receptor-neprilysin inhibitors (ARNIs) are a new class of cardiovascular agents
characterized by their dual action on the major regulators of the cardiovascular system …

[HTML][HTML] Serum uric acid predicts all-cause and cardiovascular mortality independently of hypertriglyceridemia in cardiometabolic patients without established CV …

A Mengozzi, NR Pugliese, G Desideri, S Masi, F Angeli… - Metabolites, 2023 - mdpi.com
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular
risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the …

Angiotensin receptor–neprilysin inhibitors for hypertension—hemodynamic effects and relevance to hypertensive heart disease

K Kario, B Williams - Hypertension Research, 2022 - nature.com
Angiotensin receptor–neprilysin inhibitors have multiple beneficial effects on the
cardiovascular system. The angiotensin receptor–neprilysin inhibitor sacubitril/valsartan has …

Uric acid is a biomarker for heart failure, but not therapeutic target: result from a comprehensive meta‐analysis

S Qin, M Xiang, L Gao, X Cheng, D Zhang - ESC Heart Failure, 2024 - Wiley Online Library
Aims This systematic review and meta‐analysis aimed to investigate the association
between serum uric acid (SUA) levels and the incidence rate and prognosis of heart failure …