DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of
telomerase that maintains genomic integrity. TERT expression is mostly repressed in …

Telomerase is perceived as an immortality enzyme that might provide longevity to cells and
whole organisms. Importantly, it is generally inactive in most somatic cells of healthy, adult …

Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that
restrains cancer progression at premalignant stages, in part by causing telomere …

Eight human and six chicken novel alternatively spliced (AS) variants of telomerase reverse
transcriptase (TERT) were identified, including a human variant (Δ4-13) containing an in …

Telomeres are tandem repeat DNA sequences located at distal ends of chromosomes that
protect against genomic DNA degradation and chromosomal instability. Excessive telomere …

Circadian clocks are fundamental machinery in organisms ranging from archaea to humans.
Disruption of the circadian system is associated with premature aging in mice, but the …

The ability of fluorescent small molecules, such as metal complexes, to selectively recognize
G-quadruplex (G4) structures has opened a route to develop new probes for the …

Telomere and telomerase play important roles in abnormal cell proliferation, metastasis,
stem cell maintenance, and immortalization in various cancers. Therefore, designing of …