Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same
time, these organelles generate reactive oxygen and nitrogen species as byproducts …

Reduction-oxidation or “redox” reactions are an integral part of a broad range of cellular
processes such as gene expression, energy metabolism, protein import and folding, and …

Ferroptosis is a type of nonapoptotic cell death driven by lipid peroxidation. Here, we show a
key role of MGST1 in inhibiting ferroptosis in cell cultures and mouse xenograft models …

Chemoresistance is a disturbing barrier in cancer therapy, which always results in limited
therapeutic options and unfavorable prognosis. Nuclear factor E2-related factor 2 (NRF2) …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Resistance to single or multiple chemotherapeutic drugs is a major complication in clinical
oncology and is one of the most common treatment limitations in patients with reoccurring …

The mammary gland is a prolific lipogenic organ, synthesising copious amounts of
triglycerides for secretion into milk. The fat content of milk varies widely both between and …

The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that is well-known
for regulating xenobiotic metabolism. Studies in knockout and transgenic mice indicate that …

Background Over the last years, genome-wide association studies (GWAS) based on
imputed whole-genome sequences (WGS) have been used to detect quantitative trait loci …

Significance: The multifactorial nature of the mechanisms implicated in cancer development
still represents a major issue for the success of established antitumor therapies. The …