Microfluidics for drug development: from synthesis to evaluation
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …
delivery, and drug evaluation. Compared with conventional drug development procedures …
Advances in microfluidics: technical innovations and applications in diagnostics and therapeutics
Microfluidics describes the study of systems that operate fluids at miniature scales, often in
microchannels. It is powerful in scaling down biological experiments by many orders of …
microchannels. It is powerful in scaling down biological experiments by many orders of …
Intelligent biomaterialomics: molecular design, manufacturing, and biomedical applications
Y Yi, HW An, H Wang - Advanced Materials, 2024 - Wiley Online Library
Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …
and has changed the paradigm for the research and development of new functional …
[HTML][HTML] Organ-on-a-chip meets artificial intelligence in drug evaluation
S Deng, C Li, J Cao, Z Cui, J Du, Z Fu, H Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …
industry. However, animal welfare protection and other shortcomings of traditional drug …
[HTML][HTML] iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies
VEJM Palasantzas, I Tamargo-Rubio, K Le, J Slager… - Trends in Genetics, 2023 - cell.com
Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …
variants with complex genetic diseases and drug efficacy. Functional characterization of …
Advances in organ-on-a-chip materials and devices
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
Organ-on-a-chip: A new tool for in vitro research
Abstract Organ-on-a-chip (OOC, organ chip) technology can closely simulate the human
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …
Advanced materials and sensors for microphysiological systems: focus on electronic and electrooptical interfaces
Advanced in vitro cell culture systems or microphysiological systems (MPSs), including
microfluidic organ‐on‐a‐chip (OoC), are breakthrough technologies in biomedicine. These …
microfluidic organ‐on‐a‐chip (OoC), are breakthrough technologies in biomedicine. These …
Novel pumping methods for microfluidic devices: a comprehensive review
AP Iakovlev, AS Erofeev, PV Gorelkin - Biosensors, 2022 - mdpi.com
This review is an account of methods that use various strategies to control microfluidic flow
control with high accuracy. The reviewed systems are divided into two large groups based …
control with high accuracy. The reviewed systems are divided into two large groups based …
Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system
EM Shaughnessey, SH Kann, H Azizgolshani… - Scientific Reports, 2022 - nature.com
Rapid non-invasive kidney-specific readouts are essential to maximizing the potential of
microfluidic tissue culture platforms for drug-induced nephrotoxicity screening …
microfluidic tissue culture platforms for drug-induced nephrotoxicity screening …