Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Advances in microfluidics: technical innovations and applications in diagnostics and therapeutics

G Aubry, HJ Lee, H Lu - Analytical Chemistry, 2023 - ACS Publications
Microfluidics describes the study of systems that operate fluids at miniature scales, often in
microchannels. It is powerful in scaling down biological experiments by many orders of …

Intelligent biomaterialomics: molecular design, manufacturing, and biomedical applications

Y Yi, HW An, H Wang - Advanced Materials, 2024 - Wiley Online Library
Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …

[HTML][HTML] Organ-on-a-chip meets artificial intelligence in drug evaluation

S Deng, C Li, J Cao, Z Cui, J Du, Z Fu, H Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

[HTML][HTML] iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies

VEJM Palasantzas, I Tamargo-Rubio, K Le, J Slager… - Trends in Genetics, 2023 - cell.com
Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …

Advances in organ-on-a-chip materials and devices

BK Nahak, A Mishra, S Preetam… - ACS applied bio …, 2022 - ACS Publications
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …

Organ-on-a-chip: A new tool for in vitro research

J Yan, Z Li, J Guo, S Liu, J Guo - Biosensors and Bioelectronics, 2022 - Elsevier
Abstract Organ-on-a-chip (OOC, organ chip) technology can closely simulate the human
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …

Advanced materials and sensors for microphysiological systems: focus on electronic and electrooptical interfaces

H Kavand, R Nasiri, A Herland - Advanced Materials, 2022 - Wiley Online Library
Advanced in vitro cell culture systems or microphysiological systems (MPSs), including
microfluidic organ‐on‐a‐chip (OoC), are breakthrough technologies in biomedicine. These …

Novel pumping methods for microfluidic devices: a comprehensive review

AP Iakovlev, AS Erofeev, PV Gorelkin - Biosensors, 2022 - mdpi.com
This review is an account of methods that use various strategies to control microfluidic flow
control with high accuracy. The reviewed systems are divided into two large groups based …

Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system

EM Shaughnessey, SH Kann, H Azizgolshani… - Scientific Reports, 2022 - nature.com
Rapid non-invasive kidney-specific readouts are essential to maximizing the potential of
microfluidic tissue culture platforms for drug-induced nephrotoxicity screening …