Inhibitor of apoptosis protein (IAP) antagonists in anticancer agent discovery: Current status and perspectives
H Cong, L Xu, Y Wu, Z Qu, T Bian… - Journal of Medicinal …, 2019 - ACS Publications
Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …
FBXW7 confers radiation survival by targeting p53 for degradation
The tumor suppressor p53 plays a critical role in integrating a wide variety of stress
responses. Therefore, p53 levels are precisely regulated by multiple ubiquitin ligases. In this …
responses. Therefore, p53 levels are precisely regulated by multiple ubiquitin ligases. In this …
Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy
An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-
wide and 2-nm-thick Bi 2 Se 3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and …
wide and 2-nm-thick Bi 2 Se 3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and …
Recent advances in caspase-3, breast cancer, and traditional Chinese medicine: a review
H Dou, P Yu, Y Liu, Y Zhu, F Li, Y Wang… - Journal of …, 2024 - Taylor & Francis
Caspases (cysteinyl aspartate-specific proteinases) are a group of structurally similar
proteases in the cytoplasm that can be involved in cell differentiation, programmed death …
proteases in the cytoplasm that can be involved in cell differentiation, programmed death …
Molecular pathways: targeting inhibitor of apoptosis proteins in cancer—from molecular mechanism to therapeutic application
S Fulda - Clinical Cancer Research, 2014 - AACR
Inhibitor of apoptosis (IAP) proteins play a critical role in the control of survival and cell death
by regulating key signaling events such as caspase activation and NF-κB signaling …
by regulating key signaling events such as caspase activation and NF-κB signaling …
[HTML][HTML] Inhibiting the inhibitors: Development of the IAP inhibitor xevinapant for the treatment of locally advanced squamous cell carcinoma of the head and neck
RL Ferris, K Harrington, JD Schoenfeld… - Cancer Treatment …, 2023 - Elsevier
Standard of care for patients with locally advanced squamous cell carcinoma of the head
and neck (LA SCCHN) is surgery followed by chemoradiotherapy (CRT) or definitive CRT …
and neck (LA SCCHN) is surgery followed by chemoradiotherapy (CRT) or definitive CRT …
Smac mimetics to therapeutically target IAP proteins in cancer
S Fulda - International review of cell and molecular biology, 2017 - Elsevier
Inhibitor of Apoptosis (IAP) proteins are overexpressed in a variety of human cancers.
Therefore, they are considered as promising targets for the design of therapeutic strategies …
Therefore, they are considered as promising targets for the design of therapeutic strategies …
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme
D Yang, M Tan, G Wang, Y Sun - PloS one, 2012 - journals.plos.org
Radiotherapy is a treatment choice for local control of breast cancer. However, intrinsic
radioresistance of cancer cells limits therapeutic efficacy. We have recently validated that …
radioresistance of cancer cells limits therapeutic efficacy. We have recently validated that …
[HTML][HTML] Small molecules targeting programmed cell death in breast cancer cells
Targeted chemotherapy has become the forefront for cancer treatment in recent years. The
selective and specific features allow more effective treatment with reduced side effects. Most …
selective and specific features allow more effective treatment with reduced side effects. Most …