Cancer-associated fibroblasts in the single-cell era
Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …
[HTML][HTML] Cholangiocarcinoma
PJ Brindley, M Bachini, SI Ilyas, SA Khan… - Nature reviews Disease …, 2021 - nature.com
Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system,
which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has …
which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has …
[HTML][HTML] Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma
L Goyal, F Meric-Bernstam… - … England Journal of …, 2023 - Mass Medical Soc
Background Alterations in fibroblast growth factor receptor 2 (FGFR2) have emerged as
promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer with a poor …
promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer with a poor …
Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up☆
Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up☆ -
Annals of Oncology Skip to Main Content Advertisement Annals of Oncology European Society …
Annals of Oncology Skip to Main Content Advertisement Annals of Oncology European Society …
Final overall survival efficacy results of ivosidenib for patients with advanced cholangiocarcinoma with IDH1 mutation: the phase 3 randomized clinical ClarIDHy trial
AX Zhu, T Macarulla, MM Javle, RK Kelley… - JAMA …, 2021 - jamanetwork.com
Importance Isocitrate dehydrogenase 1 (IDH1) variations occur in up to approximately 20%
of patients with intrahepatic cholangiocarcinoma. In the ClarIDHy trial, progression-free …
of patients with intrahepatic cholangiocarcinoma. In the ClarIDHy trial, progression-free …
Harnessing nanomaterials for cancer sonodynamic immunotherapy
Immunotherapy has made remarkable strides in cancer therapy over the past decade.
However, such emerging therapy still suffers from the low response rates and immune …
However, such emerging therapy still suffers from the low response rates and immune …
Infigratinib (BGJ398) in previously treated patients with advanced or metastatic cholangiocarcinoma with FGFR2 fusions or rearrangements: mature results from a …
M Javle, S Roychowdhury, RK Kelley… - The Lancet …, 2021 - thelancet.com
Background Treatment options are sparse for patients with advanced cholangiocarcinoma
after progression on first-line gemcitabine-based therapy. FGFR2 fusions or rearrangements …
after progression on first-line gemcitabine-based therapy. FGFR2 fusions or rearrangements …
[HTML][HTML] Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
L Izquierdo-Sanchez, A Lamarca, A La Casta… - Journal of …, 2022 - Elsevier
Background & Aims Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer,
whose incidence and related mortality is increasing. This study investigates the clinical …
whose incidence and related mortality is increasing. This study investigates the clinical …
[HTML][HTML] Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma
We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …
[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer
B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …
physiological processes, as well as in the onset, progression, and maintenance of cancers …