C8-linked bulky guanosine DNA adducts: experimental and computational insights into adduct conformational preferences and resulting mutagenicity
AL Millen, P Sharma, SD Wetmore - Future Medicinal Chemistry, 2012 - Taylor & Francis
Bulky DNA adducts are formed through the covalent attachment of aryl groups to the DNA
nucleobases. Many of these adducts are known to possess conformational heterogeneity …
nucleobases. Many of these adducts are known to possess conformational heterogeneity …
[PDF][PDF] Reactive electrophilic metabolites of aromatic amine and amide carcinogens
PD Josephy, M Novak - Front Biosci (Schol Ed), 2013 - article.imrpress.com
Introduction 3. Early synthetic chemistry of aromatic amines 4. Monocyclic and polycyclic
arylamines 5. Metabolic N-hydroxylation 6. Enzymatic oxidation of aromatic amines 7 …
arylamines 5. Metabolic N-hydroxylation 6. Enzymatic oxidation of aromatic amines 7 …
Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethyl p-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition …
O Pinto, J Sardinha, PD Vaz, F Piedade… - Journal of medicinal …, 2011 - ACS Publications
Intramolecular cyclization via nitrenium ion of 2-phenylpentanoic/2-phenylbutanoic acid
esters with a terminal p-azidophenyl group gives direct access to tetrahydronaphthalene …
esters with a terminal p-azidophenyl group gives direct access to tetrahydronaphthalene …
Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA
The metabolism of aromatic and heteroaromatic amines (ArNH2) results in nitrenium ions
(ArNH+) that modify nucleobases of DNA, primarily deoxyguanosine (dG), by forming dG-C8 …
(ArNH+) that modify nucleobases of DNA, primarily deoxyguanosine (dG), by forming dG-C8 …
Photochemical generation and characterization of the 5-endo-10, 11-dihydrodibenzoazepine nitrenium ion
ES Chinn, DE Falvey - Photochemical & Photobiological Sciences, 2022 - Springer
A photochemical precursor to the 5-endo-10, 11-dihydroazepine nitrenium ion (1) was
synthesized and used to characterize the intermediate by laser flash photolysis and stable …
synthesized and used to characterize the intermediate by laser flash photolysis and stable …
Conformational flexibility of C8-phenoxylguanine adducts in deoxydinucleoside monophosphates
AL Millen, BL Kamenz, FMV Leavens… - The Journal of …, 2011 - ACS Publications
M06-2X/6-31G (d, p) is used to calculate the structure of all natural deoxydinucleoside
monophosphates with G in the 5′ or 3′ position, the anti or syn conformation, and each …
monophosphates with G in the 5′ or 3′ position, the anti or syn conformation, and each …
Base-Displaced Intercalated Structure of the N-(2′-Deoxyguanosin-8-yl)-3-aminobenzanthrone DNA Adduct
3-Nitrobenzanthrone (3-NBA), an environmental mutagen found in diesel exhaust and a
suspected carcinogen, undergoes metabolic reduction followed by reaction with DNA to …
suspected carcinogen, undergoes metabolic reduction followed by reaction with DNA to …
Mechanism of Error‐Free Bypass of the Environmental Carcinogen N‐(2′‐Deoxyguanosin‐8‐yl)‐3‐aminobenzanthrone Adduct by Human DNA Polymerase η
A Patra, DA Politica, A Chatterjee, EJ Tokarsky… - …, 2016 - Wiley Online Library
The environmental pollutant 3‐nitrobenzanthrone produces bulky aminobenzanthrone
(ABA) DNA adducts with both guanine and adenine nucleobases. A major product occurs at …
(ABA) DNA adducts with both guanine and adenine nucleobases. A major product occurs at …
A salt-bridge switch in the molecular recognition between RS receptor and RGD ligand from the ABEEM σπ molecular dynamics simulations
C Zhang, DX Zhao, Q Wang, L Yu, GH Li… - Molecular …, 2017 - Taylor & Francis
How the receptor and ligand recognise each other is a challenging subject in explaining the
mechanism of recognition at the molecular level. As a starting point, here, a synthesised RS …
mechanism of recognition at the molecular level. As a starting point, here, a synthesised RS …
[图书][B] Synthesis of Site-specific DNA adducts of Aromatic Amine and Nitro-aromatic Carcinogens and Study of their Replication Properties
A Chatterjee - 2019 - search.proquest.com
A large number of nitro polycyclic aromatic hydrocarbons (nitro-PAHs) and heterocyclic
aromatic amines (HAAs) are present in the environment and many compounds of these …
aromatic amines (HAAs) are present in the environment and many compounds of these …