Myzozoans encompass apicomplexans and dinoflagellates that manifest diverse lifestyles in
highly varied environments. They show enormous propensity to employ different metabolic …

Mutations in a Plasmodium de-ubiquitinase UBP1 have been linked to antimalarial drug
resistance. However, the UBP1-mediated drug-resistant mechanism remains unknown …

Vesicular trafficking, including secretion and endocytosis, plays fundamental roles in the
unique biology of Plasmodium falciparum blood-stage parasites. Endocytosis of host cell …

Plasmodium falciparum, the causative agent of malaria, poses a significant global health
challenge, yet much of its biology remains elusive. A third of the genes in the P. falciparum …

Vesicular trafficking, including secretion and endocytosis, plays fundamental roles in the
unique biology of P. falciparum blood-stage parasites. Endocytosis of host cell cytosol …

Reduced susceptibility to ART, the first-line treatment against malaria, is common in South
East Asia (SEA). It is associated with point mutations, mostly in kelch13 (k13) but also in …

Combination therapies containing Artemisinin derivatives (ART) are the first line treatment of
malaria but their effectiveness is reduced by resistance due to a fraction of ring stage …

The recent emergence of artemisinin (ART) resistance in Plasmodium falciparum malarial
parasites is of major concern and has focused attention on the mechanism of action of ART …