Modeling the within-host dynamics of HIV infection
AS Perelson, RM Ribeiro - BMC biology, 2013 - Springer
The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …
models of human immunodeficiency virus (HIV), but now includes many viral infections …
[图书][B] Evolutionary dynamics: exploring the equations of life
MA Nowak - 2006 - books.google.com
At a time of unprecedented expansion in the life sciences, evolution is the one theory that
transcends all of biology. Any observation of a living system must ultimately be interpreted in …
transcends all of biology. Any observation of a living system must ultimately be interpreted in …
Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6 PD by passive transfer of neutralizing antibodies
JR Mascola, MG Lewis, G Stiegler, D Harris… - Journal of …, 1999 - Am Soc Microbiol
The role of antibody in protection against human immunodeficiency virus (HIV-1) has been
difficult to study in animal models because most primary HIV-1 strains do not infect …
difficult to study in animal models because most primary HIV-1 strains do not infect …
Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective
Background Why some individuals develop AIDS rapidly whereas others remain healthy
without treatment for many years remains a central question of HIV research. Of the …
without treatment for many years remains a central question of HIV research. Of the …
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
G Silvestri, DL Sodora, RA Koup, M Paiardini… - Immunity, 2003 - cell.com
HIV-infected humans and SIV-infected rhesus macaques who remain healthy despite long-
term infection exhibit exceptionally low levels of virus replication and active antiviral cellular …
term infection exhibit exceptionally low levels of virus replication and active antiviral cellular …
Vaccines against intracellular infections requiring cellular immunity
RA Seder, AVS Hill - Nature, 2000 - nature.com
Vaccines against a variety of infectious diseases represent one of the great triumphs of
medicine. The immune correlates of protection induced by most current vaccines seem to be …
medicine. The immune correlates of protection induced by most current vaccines seem to be …
Effectiveness of Postinoculation (R)-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIVmne …
CC Tsai, P Emau, KE Follis, TW Beck… - Journal of …, 1998 - Am Soc Microbiol
ABSTRACT (R)-9-(2-Phosphonylmethoxypropyl) adenine (PMPA), an acyclic nucleoside
phosphonate analog, is one of a new class of potent antiretroviral agents. Previously, we …
phosphonate analog, is one of a new class of potent antiretroviral agents. Previously, we …
Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection
RM Ribeiro, L Qin, LL Chavez, D Li, SG Self… - Journal of …, 2010 - Am Soc Microbiol
During primary infection, the number of HIV-1 particles in plasma increases rapidly, reaches
a peak, and then declines until it reaches a set point level. Understanding the kinetics of …
a peak, and then declines until it reaches a set point level. Understanding the kinetics of …
Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS
A Nichole Cline, JW Bess, MJ Piatak… - Journal of medical …, 2005 - Wiley Online Library
As new assay methods for quantitative reverse transcription‐polymerase chain reaction (RT‐
PCR), such as real time RT‐PCR techniques, approach theoretical limits of per reaction …
PCR), such as real time RT‐PCR techniques, approach theoretical limits of per reaction …