Albuminuria, a hallmark of diabetic nephropathy, reflects not only injury and dysfunction of
the filtration apparatus, but is also affected by altered glomerular hemodynamics and …

Kidney disease is a major driver of mortality among patients with diabetes and diabetic
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately …

Background Diabetic kidney disease (DKD) is responsible for close to half of all ESKD
cases. Although unbiased gene expression changes have been extensively characterized in …

Recently, epigenetic alterations have been shown to be involved in the pathogenesis of
diabetes and its complications. Kidney podocytes, which are glomerular epithelial cells, are …

Recent epigenome-wide studies suggest an association between blood DNA methylation
and kidney function. However, the pathological importance remains unclear. Here, we show …

The number of chronic kidney disease (CKD) patients is increasing worldwide, and it is
necessary to diagnose CKD patients in earlier stages to improve their prognosis. Previously …

Pituitary growth hormone (GH) is essential for growth, metabolism, and renal function.
Overactive GH signaling is associated with impaired kidney function. Glomerular podocytes …

Background Patients with diabetic or hypertensive kidney disease rarely undergo kidney
biopsy because nephrologists commonly believe that biopsy-related risk outweighs the …