Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
The role of NMDA receptors in Alzheimer's disease
J Liu, L Chang, Y Song, H Li, Y Wu - Frontiers in neuroscience, 2019 - frontiersin.org
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …
A brief history of long-term potentiation
RA Nicoll - neuron, 2017 - cell.com
Since the discovery of long-term potentiation (LTP) in 1973, thousands of papers have been
published on this intriguing phenomenon, which provides a compelling cellular model for …
published on this intriguing phenomenon, which provides a compelling cellular model for …
Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
AMPARs and synaptic plasticity: the last 25 years
RL Huganir, RA Nicoll - Neuron, 2013 - cell.com
The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …
of research in neuroscience. In the last 25 years we have come a long way in our …
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
ER Kandel - Molecular brain, 2012 - Springer
The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE,
CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the …
CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the …
Reactive oxygen species: Physiological and physiopathological effects on synaptic plasticity: Supplementary issue: Brain plasticity and repair
TF Beckhauser, J Francis-Oliveira… - Journal of …, 2016 - journals.sagepub.com
In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …
A synaptic model of memory: long-term potentiation in the hippocampus
TVP Bliss, GL Collingridge - Nature, 1993 - nature.com
Long-term potentiation of synaptic transmission in the hippocampus is the primary
experimental model for investigating the synaptic basis of learning and memory in …
experimental model for investigating the synaptic basis of learning and memory in …
Synapses and memory storage
M Mayford, SA Siegelbaum… - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The synapse is the functional unit of the brain. During the last several decades we have
acquired a great deal of information on its structure, molecular components, and …
acquired a great deal of information on its structure, molecular components, and …
LTP and LTD: an embarrassment of riches
RC Malenka, MF Bear - Neuron, 2004 - cell.com
LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …
are widespread phenomena expressed at possibly every excitatory synapse in the …