Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …

Bone morphogenetic proteins (BMPs) and their receptors, known to be essential regulators
of embryonic patterning and organogenesis, are also critical for the regulation of …

Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …

Nucleosomes cover most of the genome and are thought to be displaced by transcription
factors in regions that direct gene expression. However, the modes of interaction between …

Background Human pluripotent stem cells offer the best available model to study the
underlying cellular and molecular mechanisms of human embryonic lineage specification …

In amniotes, the development of the primitive streak and its accompanying 'organizer'define
the first stages of gastrulation. Although these structures have been characterized in detail in …

Abstract Development of the asymmetric amniotic sac—with the embryonic disc and
amniotic ectoderm occupying opposite poles—is a vital milestone during human embryo …

Efficient gene editing is essential to fully utilize human pluripotent stem cells (hPSCs) in
regenerative medicine. Custom endonuclease-based gene targeting involves two …

Human pluripotent stem cells (hPSCs) provide a valuable model for the study of human
development and a means to generate a scalable source of cells for therapeutic …

Germline–soma segregation is a fundamental event during mammalian embryonic
development. Here we establish the epigenetic principles of human primordial germ cell …