The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …

While survival has improved for Burkitt lymphoma patients, potential differences in outcome
between pediatric and adult patients remain unclear. In both age groups, survival remains …

Mitochondrial function and homeostasis are critical to the proliferation of lung cancer cells. T-
cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the …

Retinoblastoma (RB) is the most common pediatric intraocular malignancy and is a serious
vision-and life-threatening disease. The biallelic mutation of the retinoblastoma gene RB1 is …

Objectives Temozolomide (TMZ) resistance is a key factor that restricts the therapeutic effect
of glioblastoma (GBM). YTH‐domain family member 2 (YTHDF2) is highly expressed in GBM …

Menin/MEN1 is a scaffold protein that participates in proliferation, regulation of gene
transcription, DNA damage repair, and signal transduction. In hematological malignancies …

Lymphoma is a cancer affecting the lymphatic system that fights infections and diseases. In
addition to surgery, radiotherapy, and chemotherapy, novel approaches have recently been …

Among all cancer types, lung cancer has already become the leading cause of cancer-
related death around the world. The molecular mechanism understanding this development …

The germinal center (GC) reaction is a key process during an adaptive immune response to
T cell specific antigens. GCs are specialized structures within secondary lymphoid organs, in …