Simple Summary The tumor immune escape mechanisms are key factors in cancer
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …

The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …

A key mechanism of tumor resistance to immune cells is mediated by expression of peptide-
loaded HLA class I molecule (HLA-E) in tumor cells, which suppresses NK cell activity via …

Avoiding the immune rejection of transplanted T cells is central to the success of allogeneic
cancer immunotherapies. One solution to protecting T-cell grafts from immune rejection …

The broad success of adoptive immunotherapy to treat human cancer has resulted in a
paradigm shift in modern medicine. Modification of autologous and allogenic immune cells …

During mouse cytomegalovirus (CMV) infection, a population of Ly49H+ natural killer (NK)
cells expands and is responsible for disease clearance through the induction of a “memory …

Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …

Oncogenic transformation in human and experimental animals is not necessarily followed by
the appearance of a tumor mass. The immune system of the host can recognize tumor …

We have recently described a specialized subset of human natural killer (NK) cells with a
CD56 dim CD57+ NKG2C+ phenotype that expand specifically in response to …

Abstract Nonclassical HLAs, HLA-E and HLA-G, are known to affect clinical outcome in
various tumor types. We examined the clinical impact of HLA-E and HLA-G expression in …