Polycystic ovary syndrome: etiology, current management, and future therapeutics

S Singh, N Pal, S Shubham, DK Sarma… - Journal of Clinical …, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically
characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries …

The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited

RL Rosenfield, DA Ehrmann - Endocrine reviews, 2016 - academic.oup.com
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …

Potential role and therapeutic interests of myo-inositol in metabolic diseases

ML Croze, CO Soulage - Biochimie, 2013 - Elsevier
Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were
shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial …

Inositols in PCOS

Z Kamenov, A Gateva - Molecules, 2020 - mdpi.com
(1) Background: Myoinositol (MI) and D-chiro-inositol (DCI) are involved in a number of
biochemical pathways within oocytes having a role in oocyte maturation, fertilization …

Natural molecules in the management of polycystic ovary syndrome (PCOS): an analytical review

M Iervolino, E Lepore, G Forte, AS Laganà… - Nutrients, 2021 - mdpi.com
Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by chronic
ovulation dysfunction and hyperandrogenism. It is considered the most common …

Antioxidants for female subfertility

MG Showell, R Mackenzie-Proctor… - … of systematic reviews, 2020 - cochranelibrary.com
Background A couple may be considered to have fertility problems if they have been trying
to conceive for over a year with no success. This may affect up to a quarter of all couples …

Inositol in polycystic ovary syndrome: restoring fertility through a pathophysiology-based approach

AS Laganà, S Garzon, J Casarin, M Franchi… - Trends in endocrinology …, 2018 - cell.com
Myo-inositol (MI) and D-chiro-inositol (DCI) are insulin second messengers, and MI is
involved in follicular gonadotropin pathways which orchestrate ovulation. The tissue-specific …

Effects of inositol (s) in women with PCOS: a systematic review of randomized controlled trials

V Unfer, JE Nestler, ZA Kamenov… - International journal …, 2016 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology
and pathophysiology, which remains poorly understood. It affects about 5–10% of women of …

Myo-inositol in assisted reproductive technology from bench to bedside

A Etrusco, AS Laganà, V Chiantera… - Trends in Endocrinology …, 2024 - cell.com
Inositols are insulin-sensitizing compounds of promising efficacy in the management of
polycystic ovary syndrome (PCOS). On the one hand, myo-inositol (myo-ins) plays a …

Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies

P Merviel, P James, S Bouée, M Le Guillou, C Rince… - Reproductive health, 2021 - Springer
Polycystic ovary syndrome (PCOS) is marked in 30 to 40% by insulin resistance and
hyperandrogenism. Myo-inositol (MI) increases insulin sensitivity, decreases …