▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …

The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …

Within the last 15 years, multiple new signal transduction pathways within cells have been
discovered. Many of these pathways belong to what is now termed 'the mitogen-activated …

BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that regulate the
expression of approximately 60% of all human genes. They play important roles in …

Class II cytokine receptors were originally defined on the basis of sequence homologies in
the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and …

Malignant glioma is a consistently fatal brain cancer. The tumor invades the surrounding
tissue, limiting complete surgical removal and thereby initiating recurrence. Identifying …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

The mda-7 gene (approved gene symbol IL24) is a novel tumor suppressor gene with tumor-
apoptotic and immune-activating properties. We completed a Phase I dose-escalation …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …