Human granulosa cells—stemness properties, molecular cross-talk and follicular angiogenesis

C Dompe, M Kulus, K Stefańska, W Kranc, B Chermuła… - Cells, 2021 - mdpi.com
The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and
granulosa cells (GCs). Two different types of GCs, mural GCs and cumulus cells (CCs) …

The stemness of human ovarian granulosa cells and the role of resveratrol in the differentiation of MSCs—a review based on cellular and molecular knowledge

M Jozkowiak, G Hutchings, M Jankowski, K Kulcenty… - Cells, 2020 - mdpi.com
Ovarian Granulosa Cells (GCs) are known to proliferate in the developing follicle and
undergo several biochemical processes during folliculogenesis. They represent a …

The Molecular Quality and Mitochondrial Activity of Porcine Cumulus–Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds …

G Gorczyca, K Wartalski, M Romek, M Samiec… - International Journal of …, 2022 - mdpi.com
Thus far, the potential short-and long-term detrimental effects of a variety of environmental
chemicals designated as endocrine-active compounds (EACs) have been found to interfere …

Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey

D Zhang, X Zhang, M Zeng, J Yuan, M Liu, Y Yin… - Journal of assisted …, 2015 - Springer
Purpose Ovarian aging is closely tied to the decline in ovarian follicular reserve and oocyte
quality. During the prolonged reproductive lifespan of the female, granulosa cells connected …

Ovarian regeneration: the potential for stem cell contribution in the postnatal ovary to sustained endocrine function

AM Truman, JL Tilly, DC Woods - Molecular and cellular endocrinology, 2017 - Elsevier
The endocrine function of the ovary is dependent upon the ovarian follicle, which on a
cellular basis consists of an oocyte surrounded by adjacent somatic cells responsible for …

[HTML][HTML] Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance

M Tsoi, M Morin, C Rico, RL Johnson, M Paquet… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Recent reports suggest that the Hippo signaling pathway influences ovarian follicle
development; however, its exact roles remain unknown. Here, we examined the ovarian …

Characterization and identification of human immortalized granulosa cells derived from ovarian follicular fluid

A Ai, Z Tang, Y Liu, S Yu, B Li… - Experimental and …, 2019 - spandidos-publications.com
Follicular fluid serves a crucial role in follicular development and oocyte maturation.
Increasing evidence indicates that follicular fluid is rich in proteins and functional cells. In …

miR-122-5p regulates proliferation and apoptosis of chicken granulosa cells of hierarchal follicles by targeting MAPK3

G Zhang, Z Cui, J Li, D Zhang, Z Li, Z Lin, H Yin, J Ran… - Gene, 2022 - Elsevier
Chicken follicles plays a crucial role in the reproductive performance, especially in laying
period. Recently, miR-122-5p has been found to be differentially expressed in the ovaries of …

[HTML][HTML] ALG2 inhibits the epithelial-to-mesenchymal transition and stemness of ovarian granulosa cells through the Wnt/β-catenin signaling pathway in polycystic …

Q Zheng, M Liu, J Fu - Reproductive Biology, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects fertility in women of
reproductive age, and a leading cause of anovulatory infertility. Ovarian granulosa cells are …

Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth

E Babayev, M Xu, LD Shea, TK Woodruff… - Molecular human …, 2022 - academic.oup.com
Follicles are the functional unit of the ovary and several methods have been developed to
grow follicles ex vivo, which recapitulate key events of oogenesis and folliculogenesis …