Alzheimer's disease: the challenge of the second century
DM Holtzman, JC Morris, AM Goate - Science translational medicine, 2011 - science.org
Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …
Alzheimer's disease: How metal ions define β-amyloid function
KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
Amyloid-β amyloidogenesis is reported to occur via a nucleated polymerization mechanism.
If this is true, the energetically unfavorable oligomeric nucleus should be very hard to detect …
If this is true, the energetically unfavorable oligomeric nucleus should be very hard to detect …
Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta
Familial Alzheimer's disease (fAD) mutations alter amyloid precursor protein (APP) cleavage
by γ-secretase, increasing the proportion of longer amyloidogenic amyloid-β (Aβ) peptides …
by γ-secretase, increasing the proportion of longer amyloidogenic amyloid-β (Aβ) peptides …
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain
The hallmarks of Alzheimer's disease (AD) are the accumulation of Aβ plaques and
neurofibrillary tangles composed of hyperphosphorylated tau. We developed sensitive …
neurofibrillary tangles composed of hyperphosphorylated tau. We developed sensitive …
Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-β peptide
A Hatami, S Monjazeb, S Milton, CG Glabe - Journal of Biological Chemistry, 2017 - ASBMB
Most cases of Alzheimer's disease (AD) are sporadic, but a small percentage of AD cases,
called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the …
called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the …
Protein amyloids develop an intrinsic fluorescence signature during aggregation
We report observations of an intrinsic fluorescence in the visible range, which develops
during the aggregation of a range of polypeptides, including the disease-related human …
during the aggregation of a range of polypeptides, including the disease-related human …
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
S Weggen, D Beher - Alzheimer's research & therapy, 2012 - Springer
Mutations in both the amyloid precursor protein (APP) and the presenilin (PSEN) genes
cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early …
cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early …
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease
Point mutations in the amyloid-β (Aβ) coding region produce a combination of mutant and
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …
Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates
Molecular probes for selective identification of protein aggregates are important to advance
our understanding of the molecular pathogenesis underlying protein aggregation diseases …
our understanding of the molecular pathogenesis underlying protein aggregation diseases …