Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Intracranial pressure (ICP) monitoring is now viewed as integral to the clinical care of many
life-threatening brain insults, such as severe traumatic brain injury, subarachnoid …

Abstract Treatment of circulatory shock in critically ill patients requires management of blood
pressure using invasive monitoring, but uncertainty remains as to optimal individual blood …

Impaired cerebral autoregulation (CA) in moderate/severe traumatic brain injury (TBI) has
been identified as a strong associate with poor long-term outcomes, with recent data …

Background A previous retrospective single-centre study suggested that the percentage of
time spent with cerebral perfusion pressure (CPP) below the individual lower limit of …

Background The primary aim was to explore the association of global cerebral physiological
variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral …

The aim of this study was to investigate if the absolute pressure reactivity index (PRx) value
influenced the association between cerebral perfusion pressure (CPP) and outcome and if …

Introduction Multimodality monitoring of patients with severe traumatic brain injury (TBI) is
primarily performed in neuro-critical care units to prevent secondary harmful brain insults …

The cerebral oxygen cascade includes three key stages:(a) convective oxygen delivery
representing the bulk flow of oxygen to the cerebral vascular bed;(b) diffusion of oxygen from …