Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …

Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …

Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

Liver fibrosis results from repeated and persistent liver damage. It can start with hepatocyte
injury and advance to inflammation, which recruits and activates additional liver immune …

Liver fibrosis accompanies the progression of chronic liver diseases independent of
etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated …

Abstract The pathophysiology of Non-Alcoholic Steatohepatitis (NASH) encompasses a
complex set of intra-and extrahepatic driving mechanisms, involving numerous metabolic …

The number of patients with nonalcoholic fatty liver disease (NAFLD)/nonalcoholic
steatohepatitis (NASH) is increasing globally and is raising serious concerns regarding the …

The pathogenesis of metabolic-associated fatty liver disease (MAFLD) is complex and
thought to be dependent on multiple parallel hits on a background of genetic susceptibility …