Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Y Wang, G Zhan, Z Cai, B Jiao, Y Zhao, S Li… - … & Biobehavioral Reviews, 2021 - Elsevier
Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

[HTML][HTML] Vagal nerve stimulation for treatment-resistant depression

FR Carreno, A Frazer - Neurotherapeutics, 2017 - Elsevier
Major depressive disorder (MDD) is prevalent. Although standards antidepressants are
more effective than placebo, up to 35% of patients do not respond to 4 or more conventional …

Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder: a nonrandomized controlled pilot study

P Rong, J Liu, L Wang, R Liu, J Fang, J Zhao… - Journal of Affective …, 2016 - Elsevier
Background Depression presents a significant burden to both patients and society. One
treatment that has emerged is vagus nerve stimulation (VNS), an FDA-approved physical …

Reorganization of motor cortex by vagus nerve stimulation requires cholinergic innervation

DR Hulsey, SA Hays, N Khodaparast, A Ruiz, P Das… - Brain stimulation, 2016 - Elsevier
Background Vagus nerve stimulation (VNS) paired with forelimb training drives robust,
specific reorganization of movement representations in the motor cortex. The mechanisms …

Vagus nerve stimulation boosts the drive to work for rewards

MP Neuser, V Teckentrup, A Kühnel… - Nature …, 2020 - nature.com
Interoceptive feedback transmitted via the vagus nerve plays a vital role in motivation by
tuning actions according to physiological needs. Whereas vagus nerve stimulation (VNS) …

No modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS)

M Keute, M Demirezen, A Graf, NG Mueller, T Zaehle - Scientific reports, 2019 - nature.com
Transcutaneous auricular vagus nerve stimulation (taVNS) bears therapeutic potential for a
wide range of medical conditions. However, previous studies have found substantial …

Recent advances in devices for vagus nerve stimulation

A Mertens, R Raedt, S Gadeyne, E Carrette… - Expert review of …, 2018 - Taylor & Francis
Introduction: Vagus nerve stimulation (VNS) has become a valuable treatment option for
refractory epilepsy and depression. To improve clinical efficacy and minimize side effects …

Vagus nerve stimulation: state of the art of stimulation and recording strategies to address autonomic function neuromodulation

D Guiraud, D Andreu, S Bonnet… - Journal of neural …, 2016 - iopscience.iop.org
Objective. Neural signals along the vagus nerve (VN) drive many somatic and autonomic
functions. The clinical interest of VN stimulation (VNS) is thus potentially huge and has …

Noradrenergic alterations in Parkinson's disease: a combined 11C-yohimbine PET/neuromelanin MRI study

C Laurencin, S Lancelot, S Brosse, I Mérida, J Redouté… - Brain, 2024 - academic.oup.com
Degeneration of the noradrenergic system is now considered a pathological hallmark of
Parkinson's disease, but little is known about its consequences in terms of parkinsonian …

Closed-loop implantable therapeutic neuromodulation systems based on neurochemical monitoring

KB Mirza, CT Golden, K Nikolic… - Frontiers in …, 2019 - frontiersin.org
Closed-loop or intelligent neuromodulation allows adjustable, personalized
neuromodulation which usually incorporates the recording of a biomarker, followed by …