A pooled cell painting CRISPR screening platform enables de novo inference of gene function by self-supervised deep learning

S Sivanandan, B Leitmann, E Lubeck, MM Sultan… - bioRxiv, 2023 - biorxiv.org
Pooled CRISPR screening has emerged as a powerful method of mapping gene functions
thanks to its scalability, affordability, and robustness against well or plate-specific …

[HTML][HTML] CROPseq-multi: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens

RT Walton, Y Qin, PC Blainey - bioRxiv, 2024 - ncbi.nlm.nih.gov
Forward genetic screens seek to dissect complex biological systems by systematically
perturbing genetic elements and observing the resulting phenotypes. While standard …