Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …

Phenotypic traits are products of two processes: evolution and development. But how do
these processes combine to produce integrated phenotypes? Comparative studies identify …

The bone morphogenetic proteins (BMPs) are a group of potent morphogens which are
critical for the patterning, development, and function of the central nervous system. The …

Abstract Background This Phase 1 study evaluates the intra-and peritumoral administration
by convection enhanced delivery (CED) of human recombinant Bone Morphogenetic Protein …

Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of
tumors. Most mechanistic studies focus on their static functional status before or after …

Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the
degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding …

Previously, we showed that after Freund's adjuvant-induced peritonitis, rat mesothelial cells
regain their epithelial phenotype through mesenchymal-epithelial transition (MET) …

Glioblastoma (GBM) is the most common and highly lethal type of brain tumor, with poor
survival despite advances in understanding its complexity. After current standard therapeutic …

Neural progenitor cell (NPC) transplantation is a promising technique for central nervous
system (CNS) reconstruction and regeneration. Biomaterial scaffolds, frameworks, and …

Background Glioblastoma (GBM) is the most aggressive primary brain tumor. Its cellular
composition is very heterogeneous, with cells exhibiting stem-cell characteristics (GSCs) …