Stress-induced reinstatement of drug seeking: 20 years of progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence
High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
The neurobiology of food intake in an obesogenic environment
HR Berthoud - Proceedings of the Nutrition Society, 2012 - cambridge.org
The objective of this non-systematic review of the literature is to highlight some of the neural
systems and pathways that are affected by the various intake-promoting aspects of the …
systems and pathways that are affected by the various intake-promoting aspects of the …
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
Background and rationale The reinstatement model is widely used to study relapse to drug
addiction. However, the model's validity is open to question. Objective We assess the …
addiction. However, the model's validity is open to question. Objective We assess the …
Circuit and synaptic plasticity mechanisms of drug relapse
High rates of relapse to drug use during abstinence is a defining feature of human drug
addiction. This clinical scenario has been studied at the preclinical level using different …
addiction. This clinical scenario has been studied at the preclinical level using different …
Factors modulating the incubation of drug and non-drug craving and their clinical implications
It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …
early abstinence and remains high during extended periods of time. Clinical evidence now …
Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review
Studies in humans suggest that exposure to life stressors is correlated with compulsive drug
abuse and relapse to drugs during periods of abstinence. The behavioral and …
abuse and relapse to drugs during periods of abstinence. The behavioral and …
Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications
JM Bossert, UE Ghitza, L Lu, DH Epstein… - European journal of …, 2005 - Elsevier
The central problem in the treatment of cocaine and heroin addiction is high rates of relapse
to drug use after periods of forced or self-imposed abstinence. Relapse can be modeled in …
to drug use after periods of forced or self-imposed abstinence. Relapse can be modeled in …
Selective antagonism at dopamine D3 receptors prevents nicotine-triggered relapse to nicotine-seeking behavior
M Andreoli, M Tessari, M Pilla, E Valerio… - …, 2003 - nature.com
Drugs of abuse, including, nicotine have been shown to enhance brain reward functions in
the mesocortico-limbic dopamine (DA) system in general, and the nucleus accumbens in …
the mesocortico-limbic dopamine (DA) system in general, and the nucleus accumbens in …
Effect of selective lesions of nucleus accumbens µ-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with novel Oprm1 …
JM Bossert, CA Mejias-Aponte, T Saunders… - Journal of …, 2023 - Soc Neuroscience
The brain µ-opioid receptor (MOR) is critical for the analgesic, rewarding, and addictive
effects of opioid drugs. However, in rat models of opioid-related behaviors, the circuit …
effects of opioid drugs. However, in rat models of opioid-related behaviors, the circuit …