Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Association of semaglutide with risk of suicidal ideation in a real-world cohort
W Wang, ND Volkow, NA Berger, PB Davis… - Nature medicine, 2024 - nature.com
Concerns over reports of suicidal ideation associated with semaglutide treatment, a
glucagon-like peptide 1 receptor (GLP1R) agonist medication for type 2 diabetes (T2DM) …
glucagon-like peptide 1 receptor (GLP1R) agonist medication for type 2 diabetes (T2DM) …
An increase in the omega-6/omega-3 fatty acid ratio increases the risk for obesity
AP Simopoulos - Nutrients, 2016 - mdpi.com
In the past three decades, total fat and saturated fat intake as a percentage of total calories
has continuously decreased in Western diets, while the intake of omega-6 fatty acid …
has continuously decreased in Western diets, while the intake of omega-6 fatty acid …
Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly
Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …
Antioxidant, anti-obesity, nutritional and other beneficial effects of different chili pepper: A review
Fruits and vegetables are important components of a healthy diet. They are rich sources of
vitamins and minerals, dietary fibre and a host of beneficial non-nutrient substances …
vitamins and minerals, dietary fibre and a host of beneficial non-nutrient substances …
From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
Neurobiological interactions between stress and the endocannabinoid system
Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …
many neurobehavioral processes. A growing body of work indicates that the …
Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …
discovery of several promising drug targets and novel therapeutic strategies to address the …
Progress and challenges in anti-obesity pharmacotherapy
DH Bessesen, LF Van Gaal - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Obesity is a serious and growing worldwide health challenge. Healthy lifestyle choices are
the foundation of obesity treatment. However, weight loss can lead to physiological …
the foundation of obesity treatment. However, weight loss can lead to physiological …