T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Mature B lymphocytes (B cells) recognize antigens using their B cell receptor (BCR) and are
activated to become antibody-producing cells. In addition, and integral to the development of …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …

In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in
several mouse and human haplotypes has increased our understanding of the molecular …

Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …

The nonclassical major histocompatibility complex of class II molecules (ncMHCII) HLA‐DM
(DM) and HLA‐DO (DO) feature essential functions for the selection of the peptides that are …

Dendritic cells are the antigen presenting cells that process antigens effectively and prime
the immune system, a characteristic that have gained them the spotlights in recent years. B …

Recently, crystal structures of key complexes in antigen presentation have been reported.
HLA-DM functions in antigen presentation by catalyzing dissociation of an invariant chain …

Presentation of antigenic peptides on MHC-II molecules is essential for tolerance to self and
for initiation of immune responses against foreign antigens. DO (HLA-DO in humans, H2-O …