Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …

Inflammatory bowel disease (IBD) is a chronic relapsing–remitting systemic disease of the
gastrointestinal tract, characterized by an inflammatory process that requires lifelong …

Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …

The epidemiology of inflammatory bowel disease (IBD) has undergone considerable shifts
since its emergence in the Western world over a century ago, especially in the last few …

Background Patients infected with the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide …

Background & Aims We analyzed DNA methylation patterns and transcriptomes of primary
intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel …

Background Early life exposures impact immune system development and therefore the risk
of immune-mediated diseases, including inflammatory bowel disease (IBD). We …

Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Conventional genetic testing of individuals with neurodevelopmental presentations and
congenital anomalies (ND/CAs), ie, the analysis of sequence and copy number variants …

Inflammatory bowel diseases (IBD) are chronic intermittent inflammatory disorders of the
gastrointestinal tract of unknown etiology but a clear genetic predisposition. Prompted by the …