Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics

X Tan, JH Letendre, JJ Collins, WW Wong - Cell, 2021 - cell.com
Synthetic biology is a design-driven discipline centered on engineering novel biological
functions through the discovery, characterization, and repurposing of molecular parts …

Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies

P Berry, S Khanna - BioDrugs, 2023 - Springer
Clostridioides difficile is one of the most important causes of healthcare-associated diarrhea.
The high incidence and recurrence rates of C. difficile infection, as well as its associated …

[HTML][HTML] Frontiers in antibiotic alternatives for Clostridioides difficile infection

M Phanchana, P Harnvoravongchai… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Clostridioides difficile (C. difficile) is a gram-positive, anaerobic spore-forming bacterium and
a major cause of antibiotic-associated diarrhea. Humans are naturally resistant to C. difficile …

The role of faecal microbiota transplantation: looking beyond Clostridioides difficile infection

S D. Goldenberg, B Merrick - Therapeutic advances in …, 2021 - journals.sagepub.com
Faecal microbiota transplantation (FMT) is the transfer of screened and minimally processed
faecal material from a 'healthy'donor to 'diseased'recipient. It has an established role, and is …

Microbiota-Based Live Biotherapeutic Products for Clostridioides Difficile Infection- The Devil is in the Details

L Monday, G Tillotson, T Chopra - Infection and Drug Resistance, 2024 - Taylor & Francis
Clostridioides difficile infection (CDI) remains a significant contributor to healthcare costs
and morbidity due to high rates of recurrence. Currently, available antibiotic treatment …

[HTML][HTML] Clostridioides difficile infection: Landscape and microbiome therapeutics

BJ Gawey, S Khanna - Gastroenterology & Hepatology, 2023 - ncbi.nlm.nih.gov
Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and
is common in the community. Both younger individuals who may be healthy otherwise and …

Safety of fecal microbiota transplantation for Clostridioides difficile infection focusing on pathobionts and SARS-CoV-2

D Yadav, S Khanna - Therapeutic Advances in …, 2021 - journals.sagepub.com
Clostridioides difficile infection (CDI) is a consequence of flagrant use of antibiotics, an
aging population with increasing comorbidities, and increased hospitalizations. The …

Fecal microbiota spores, live-brpk (VOWST™/VOS) for prevention of recurrent Clostridioides difficile infection

P Berry, S Khanna - Future Microbiology, 2024 - Taylor & Francis
Clostridioides difficile infection (CDI) is a health crisis comprising a majority of healthcare-
associated infections and is now being seen in the community. Persistent dysbiosis despite …

Follow your Gut: Microbiome-Based Approaches in the Developmental Pipeline for the Prevention and Adjunctive Treatment of Clostridioides difficile Infection (CDI)

AJ Gonzales-Luna, TJ Carlson - Current Infectious Disease Reports, 2020 - Springer
Abstract Purpose of Review Antibiotic use is the most important modifiable risk factor for the
development of Clostridioides difficile infection (CDI). In addition, up to a quarter of patients …