The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …

Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …

Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical,
emotional, and economic consequences for patients, families, and society at large. Timely …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Microglia and astrocytes become reactive following traumatic brain injury (TBI). However,
the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we …

Neurogenesis must be properly regulated to ensure that cell production does not exceed the
requirements of the growing cerebral cortex, yet our understanding of mechanisms that …

The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …

Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …