[HTML][HTML] A review on the medicinal chemistry of sodium glucose co-transporter 2 inhibitors (SGLT2-I): Update from 2010 to present
Diabetes mellitus (DM) is one of the leading causes of death by World Health Organization
in 2019 and is considered a significant cause of other diseases including heart attack …
in 2019 and is considered a significant cause of other diseases including heart attack …
Design, synthesis and antidiabetic study of triazole clubbed indole derivatives as α-glucosidase inhibitors
Abstract α-Glucosidase is an enzyme present near the brush boundary of the small intestine
that is essential in the hydrolysis of carbohydrates to glucose. Because inhibiting this …
that is essential in the hydrolysis of carbohydrates to glucose. Because inhibiting this …
Identification of potential N-substituted 5-benzylidenethiazolidine-2, 4‑dione derivatives as α-amylase inhibitors: Computational cum synthetic studies
Diabetes mellitus is a chronic metabolic disorder become a major health problem globally
associated with social and economic consequences. α-amylase is an endo-amylase …
associated with social and economic consequences. α-amylase is an endo-amylase …
Exploring novel lead scaffolds for SGLT2 inhibitors: Insights from machine learning and molecular dynamics simulations
Y Yu, Y Xia, G Liang - International Journal of Biological Macromolecules, 2024 - Elsevier
Abstract Sodium-glucose cotransporter 2 (SGLT2) plays a pivotal role in mediating glucose
reabsorption within the renal filtrate, representing a well-known target in type 2 diabetes and …
reabsorption within the renal filtrate, representing a well-known target in type 2 diabetes and …
DWI metrics differentiating benign intraductal papillary mucinous neoplasms from invasive pancreatic cancer: a study in GEM models
Simple Summary Intraductal papillary mucinous neoplasms (IPMN) are common
premalignant precursors to pancreatic ductal adenocarcinoma (PDAC). However, current …
premalignant precursors to pancreatic ductal adenocarcinoma (PDAC). However, current …
Multistage in silico approach to identify novel quinoline derivatives as potential c-kit kinase inhibitors
Abstract The type II-C-KIT signaling network has been extensively studied for its potential as
a target for cancer treatment, leading to the investigation of quinoline derivatives as …
a target for cancer treatment, leading to the investigation of quinoline derivatives as …
Ligand-based and structure-based virtual screening of new sodium glucose cotransporter type 2 inhibitors
AK Estrada, D Mendez-Alvarez… - Medicinal …, 2023 - ingentaconnect.com
Background: Diabetes mellitus is a metabolic disease that causes multiple complications
and common comorbidities, which decreases the quality of life for people affected by the …
and common comorbidities, which decreases the quality of life for people affected by the …
Repurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: Computational modelling studies
MM Alshehri, AU Danazumi… - Journal of …, 2024 - Taylor & Francis
Abstract Ubiquitin specific protease 30 (USP30) has been attributed to mitochondrial
dysfunction and impediment of mitophagy in Parkinson's disease (PD). This happens once …
dysfunction and impediment of mitophagy in Parkinson's disease (PD). This happens once …
Application of MIA-QSAR in Designing New Protein P38 MAP Kinase Compounds Using a Genetic Algorithm
M Mirshafiei, A Niazi… - Periodica Polytechnica …, 2023 - pp.omikk.bme.hu
Multivariate image analysis quantitative structure-activity relationship (MIA-QSAR) study
aims to obtain information from a descriptor set, which are image pixels of two-dimensional …
aims to obtain information from a descriptor set, which are image pixels of two-dimensional …
Novel indole based fused triazole-thiadiazole derivatives as anti-diabetic agents: in vitro and in silico approaches
Aim: The current research presents novel library of indole derived fused triazole-thiadiazole
derivatives (1–17) for treatment of diabetes mellitus. Methods & results: These compounds …
derivatives (1–17) for treatment of diabetes mellitus. Methods & results: These compounds …