Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

[HTML][HTML] Biology and Cultural Importance of the Narwhal

MT Nweeia - Annual Review of Animal Biosciences, 2024 - annualreviews.org
Though narwhal have survived multiple ice ages, including 2.5 Ma and the last interglacial
period with warming temperatures, Arctic climate change during the Anthropocene …

Causes and Consequences of Varying Transposable Element Activity: An Evolutionary Perspective

AJ Betancourt, KHC Wei, Y Huang… - Annual Review of …, 2024 - annualreviews.org
Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes,
including humans. This evolutionary success of TEs is due to their replicative activity …

[HTML][HTML] Autonomous transposons tune their sequences to ensure somatic suppression

İA Ilık, P Glažar, K Tse, B Brändl, D Meierhofer… - Nature, 2024 - nature.com
Transposable elements (TEs) are a major constituent of human genes, occupying
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …

[HTML][HTML] The evolution of antimicrobial peptides in Chiroptera

FX Castellanos, D Moreno-Santillán… - Frontiers in …, 2023 - frontiersin.org
High viral tolerance coupled with an extraordinary regulation of the immune response
makes bats a great model to study host-pathogen evolution. Although many immune-related …

[HTML][HTML] GWAS reveals determinants of mobilization rate and dynamics of an active endogenous retrovirus of cattle

L Tang, B Swedlund, S Dupont, C Harland… - Nature …, 2024 - nature.com
Five to ten percent of mammalian genomes is occupied by multiple clades of endogenous
retroviruses (ERVs), that may count thousands of members. New ERV clades arise by …

Genomics expands the mammalverse

NS Upham, MJ Landis - Science, 2023 - science.org
Mammal genomics has progressed at an uneven pace—half sloth, half cheetah—owing to
various technical obstacles, including the complexity of eukaryotic genomes, difficulties …

[HTML][HTML] Species-aware dna language models capture regulatory elements and their evolution

A Karollus, J Hingerl, D Gankin, M Grosshauser… - Genome Biology, 2024 - Springer
Background The rise of large-scale multi-species genome sequencing projects promises to
shed new light on how genomes encode gene regulatory instructions. To this end, new …

Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo

ME Oomen, ME Torres-Padilla - EMBO reports, 2024 - embopress.org
Remnants of transposable elements (TEs) are widely expressed throughout mammalian
embryo development. Originally infesting our genomes as selfish elements and acting as a …

[HTML][HTML] SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells

D Sun, Y Zhu, W Peng, S Zheng, J Weng, S Dong, J Li… - Genome Biology, 2024 - Springer
Background Transposable elements play a critical role in maintaining genome architecture
during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of …