Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
[HTML][HTML] Biology and Cultural Importance of the Narwhal
MT Nweeia - Annual Review of Animal Biosciences, 2024 - annualreviews.org
Though narwhal have survived multiple ice ages, including 2.5 Ma and the last interglacial
period with warming temperatures, Arctic climate change during the Anthropocene …
period with warming temperatures, Arctic climate change during the Anthropocene …
Causes and Consequences of Varying Transposable Element Activity: An Evolutionary Perspective
Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes,
including humans. This evolutionary success of TEs is due to their replicative activity …
including humans. This evolutionary success of TEs is due to their replicative activity …
[HTML][HTML] Autonomous transposons tune their sequences to ensure somatic suppression
Transposable elements (TEs) are a major constituent of human genes, occupying
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …
[HTML][HTML] The evolution of antimicrobial peptides in Chiroptera
FX Castellanos, D Moreno-Santillán… - Frontiers in …, 2023 - frontiersin.org
High viral tolerance coupled with an extraordinary regulation of the immune response
makes bats a great model to study host-pathogen evolution. Although many immune-related …
makes bats a great model to study host-pathogen evolution. Although many immune-related …
[HTML][HTML] GWAS reveals determinants of mobilization rate and dynamics of an active endogenous retrovirus of cattle
Five to ten percent of mammalian genomes is occupied by multiple clades of endogenous
retroviruses (ERVs), that may count thousands of members. New ERV clades arise by …
retroviruses (ERVs), that may count thousands of members. New ERV clades arise by …
[HTML][HTML] Species-aware dna language models capture regulatory elements and their evolution
Background The rise of large-scale multi-species genome sequencing projects promises to
shed new light on how genomes encode gene regulatory instructions. To this end, new …
shed new light on how genomes encode gene regulatory instructions. To this end, new …
Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo
ME Oomen, ME Torres-Padilla - EMBO reports, 2024 - embopress.org
Remnants of transposable elements (TEs) are widely expressed throughout mammalian
embryo development. Originally infesting our genomes as selfish elements and acting as a …
embryo development. Originally infesting our genomes as selfish elements and acting as a …
[HTML][HTML] SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
D Sun, Y Zhu, W Peng, S Zheng, J Weng, S Dong, J Li… - Genome Biology, 2024 - Springer
Background Transposable elements play a critical role in maintaining genome architecture
during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of …
during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of …