Ferritin, which includes twenty-four light and heavy chains in varying proportions in different
tissues, is primarily responsible for maintaining the body's iron metabolism. Its normal value …

Deferasirox (DFX) has recently been used to treat thalassemia with iron overload; however,
its long-term effectiveness and safety await multi-year studies. In this study, a systematic …

Purpose Iron toxicity occurs under iron-overloaded settings, such as a high iron diet and
blood transfusion, and damages important organs. Vanillin has been proven to have …

Beta-thalassemia is a genetic disorder characterized by the impaired synthesis of the
betaglobin chain of adult hemoglobin. The disorder has a complex pathophysiology that …

Panaxadiol saponin (PND) is a latent targeted drug for the treatment of aplastic anemia (AA).
In this study, we examined the effects of PND on ferroptosis in iron-overload AA and Meg-01 …

Background Iron-overload is one of the risk factors in susceptible individuals. Iron-overload
causes complications such as diastolic dysfunction, arrhythmias, ventricular dilation, and …

Objective (s): The current work aimed to assess whether curcumin and baicalein can chelate
iron in aplastic anemia (AA) complicated with iron overload, exploring the potential …

Background and aim Iron overload is commonly observed during the course of aplastic
anemia (AA), which is believed to aggravate hematopoiesis, cause multiple organ …

Background Iron deposition distorts the local magnetic field exerting T2* signal decay.
Biopsy, serum ferritin, echocardiography are not reliable to adjust iron chelation therapy …

Background. Patients with β‐thalassemia major depend on lifelong transfusion, resulting in
tissue iron overload. This longitudinal retrospective observational study aims to assess …