Chemical approaches to optimize the properties of organic fluorophores for imaging and sensing

G Jiang, H Liu, H Liu, G Ke, TB Ren… - Angewandte …, 2024 - Wiley Online Library
Organic fluorophores are indispensable tools in cells, tissue and in vivo imaging, and have
enabled much progress in the wide range of biological and biomedical fields. However …

Mitochondrial dynamics at different levels: from cristae dynamics to interorganellar cross talk

AK Kondadi, AS Reichert - Annual Review of Biophysics, 2024 - annualreviews.org
Mitochondria are essential organelles performing important cellular functions ranging from
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …

Self-inspired learning for denoising live-cell super-resolution microscopy

L Qu, S Zhao, Y Huang, X Ye, K Wang, Y Liu, X Liu… - Nature …, 2024 - nature.com
Every collected photon is precious in live-cell super-resolution (SR) microscopy. Here, we
describe a data-efficient, deep learning-based denoising solution to improve diverse SR …

Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe

S Zheng, N Dadina, D Mozumdar, L Lesiak… - Nature Chemical …, 2024 - nature.com
The inner mitochondrial membrane (IMM) generates power to drive cell function, and its
dynamics control mitochondrial health and cellular homeostasis. Here, we describe the cell …

Orange-emissive carbon dots with high photostability for mitochondrial dynamics tracking in living cells

N Xin, D Gao, B Su, T Zhou, Y Zhu, C Wu, D Wei… - ACS …, 2023 - ACS Publications
Mitochondria play significant roles in maintaining a stable internal environment for cell
metabolism. Hence, real-time monitoring of the dynamics of mitochondria is essential for …

Stimulated emission depletion microscopy

G Lukinavičius, J Alvelid, R Gerasimaitė… - Nature Reviews …, 2024 - nature.com
In this Primer, we focus on the most recent advancements in stimulated emission depletion
(STED) microscopy, encompassing optics, computational microscopy and probes design …

Orange/far-red hybrid voltage indicators with reduced phototoxicity enable reliable long-term imaging in neurons and cardiomyocytes

S Liu, J Ling, P Chen, C Cao, L Peng… - Proceedings of the …, 2023 - National Acad Sciences
Hybrid voltage indicators (HVIs) are chemogenetic sensors that combines the superior
photophysical properties of organic dyes and the genetic targetability of protein sensors to …

Mitochondrial structure, dynamics, and physiology: light microscopy to disentangle the network

JC Landoni, T Kleele, J Winter, W Stepp… - Annual Review of …, 2024 - annualreviews.org
Mitochondria serve as energetic and signaling hubs of the cell: This function results from the
complex interplay between their structure, function, dynamics, interactions, and molecular …

Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy

S Ahola, LA Pazurek, F Mayer, P Lampe… - Science …, 2024 - science.org
Mitochondrial fusion and fission accompany adaptive responses to stress and altered
metabolic demands. Inner membrane fusion and cristae morphogenesis depends on optic …

A Mitochondrion‐Inspired Magnesium–Oxygen Biobattery with High Energy Density In Vivo

E He, J Ren, L Wang, F Li, L Li, T Ye, Y Jiao… - Advanced …, 2023 - Wiley Online Library
Implantable batteries are urgently needed as a power source to meet the demands of the
next generation of biomedical electronic devices. However, existing implantable batteries …