Tackling the emerging threat of antifungal resistance to human health
Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
[HTML][HTML] Immune defence to invasive fungal infections: A comprehensive review
B Pathakumari, G Liang, W Liu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The fungal infections are relatively common in humans that can range from common, mild
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …
Ten decadal advances in fungal biology leading towards human well-being
Fungi are an understudied resource possessing huge potential for developing products that
can greatly improve human well-being. In the current paper, we highlight some important …
can greatly improve human well-being. In the current paper, we highlight some important …
Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria
Antibiotics are a modifiable iatrogenic risk factor for the most common human nosocomial
fungal infection, invasive candidiasis, yet the underlying mechanisms remain elusive. We …
fungal infection, invasive candidiasis, yet the underlying mechanisms remain elusive. We …
CARD–BCL-10–MALT1 signalling in protective and pathological immunity
J Ruland, L Hartjes - Nature Reviews Immunology, 2019 - nature.com
Abstract CARD protein–BCL-10–MALT1 (CBM) signalosomes are multiprotein signalling
platforms that control immune and inflammatory pathways in most tissues. After exposure to …
platforms that control immune and inflammatory pathways in most tissues. After exposure to …
Practice parameter for the diagnosis and management of primary immunodeficiency
FA Bonilla, DA Khan, ZK Ballas, J Chinen… - Journal of Allergy and …, 2015 - Elsevier
The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …
Immunity to fungi in the lung
LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
Neutrophil swarming delays the growth of clusters of pathogenic fungi
Neutrophils employ several mechanisms to restrict fungi, including the action of enzymes
such as myeloperoxidase (MPO) or NADPH oxidase, and the release of neutrophil …
such as myeloperoxidase (MPO) or NADPH oxidase, and the release of neutrophil …
Inherited CARD9 deficiency: invasive disease caused by ascomycete fungi in previously healthy children and adults
E Corvilain, JL Casanova, A Puel - Journal of clinical immunology, 2018 - Springer
Autosomal recessive CARD9 deficiency underlies life-threatening, invasive fungal infections
in otherwise healthy individuals normally resistant to other infectious agents. In less than 10 …
in otherwise healthy individuals normally resistant to other infectious agents. In less than 10 …
CARD9-dependent neutrophil recruitment protects against fungal invasion of the central nervous system
RA Drummond, AL Collar, M Swamydas… - PLoS …, 2015 - journals.plos.org
Candida is the most common human fungal pathogen and causes systemic infections that
require neutrophils for effective host defense. Humans deficient in the C-type lectin pathway …
require neutrophils for effective host defense. Humans deficient in the C-type lectin pathway …